腺病毒脑膜炎和脑囊尾蚴病合并感染：来自印度的首例病例。

Adenovirus Meningoencephalitis and Neurocysticercosis Co-infection: First Case from India.

机构信息

Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Department of General Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

出版信息

Infect Disord Drug Targets. 2023;23(5):e290323215132. doi: 10.2174/1871526523666230329123428.

DOI:10.2174/1871526523666230329123428

PMID:36999426

Abstract

BACKGROUND

Adenovirus generally causes upper and lower respiratory tract infections. It is common in children and occasionally in adults. Neurological involvement is rare, which may be mild aseptic meningitis to potentially fatal acute necrotizing encephalopathy. Recently, viruses have been reported increasingly to cause CNS infections. Viral aetiology typically varies with age.

CASE PRESENTATION

Here, we report an unusual adenovirus meningoencephalitis with a co-infection of neurocysticercosis in an immunocompetent adult patient. An 18-year-old healthy female student was admitted with fever and headache for 11 days and progressive altered behaviour for 5 days, followed by altered sensorium for 3 days. This variable and unusual presentation of adenoviral infection involving CNS provoked diagnostic difficulties, but with the help of advanced diagnostics, especially molecular, exact aetiology was detected. Even with the neurocysticercosis infection in this patient, the outcome was not adversely affected.

CONCLUSION

This unusual co-infection with a successful outcome is the first case of this type in literature.

摘要

背景

腺病毒通常会引起上呼吸道和下呼吸道感染。它在儿童中很常见，偶尔也会在成人中出现。神经受累很少见，可能是轻度无菌性脑膜炎，也可能是潜在致命的急性坏死性脑病。最近，越来越多的病毒被报道会引起中枢神经系统感染。病毒病因通常随年龄而变化。

病例介绍

本文报告了一例免疫功能正常的成年患者合并神经囊虫病的不常见腺病毒脑膜脑炎。一名 18 岁的健康女学生因发热和头痛 11 天，进行性行为改变 5 天，随后意识改变 3 天而入院。腺病毒感染累及中枢神经系统的这种多变且不常见的表现引发了诊断困难，但借助先进的诊断方法，特别是分子诊断，明确了病因。即使该患者合并有神经囊虫病感染，其预后也未受到不良影响。