一名健康婴儿患腺病毒所致脑膜脑炎，临床表现酷似严重细菌性败血症。
Meningoencephalitis due to adenovirus in a healthy infant mimicking severe bacterial sepsis.
作者信息
Reyes-Andrade Joaquin, Sánchez-Céspedes Javier, Olbrich Peter, Falcon Lola, Sanchez-Ganfornina Inmaculada, Tebruegge Marc, Pérez-Romero Pilar, Neth Olaf
机构信息
From the *Unidad de Enfermedades Infecciosas e Inmunopatologías Pediátrica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío; †Unidad Clínica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla; ‡Unidad de Cuidados Intensivos Pediátrica, Hospital Universitario Virgen del Rocío, Sevilla, Spain; §Academic Unit of Clinical and Experimental Sciences; ¶Institute for Life Sciences, University of Southampton, United Kingdom; and ‖Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia.
出版信息
Pediatr Infect Dis J. 2014 Apr;33(4):416-9. doi: 10.1097/INF.0000000000000128.
We present the case of a previously healthy 15-month-old girl with acute adenovirus infection who had features of severe bacterial sepsis and meningitis. Real-time qPCR done on cerebrospinal fluid identified adenovirus as the causative agent allowing stopping antibiotic treatment. The patient subsequently recovered without sequelae. An overview of published and unpublished data on adenovirus central nervous system infection in immunocompetent children is presented.
我们报告了一例先前健康的15个月大女孩，她患有急性腺病毒感染，具有严重细菌性败血症和脑膜炎的特征。对脑脊液进行的实时定量聚合酶链反应（qPCR）确定腺病毒为病原体，从而停止了抗生素治疗。患者随后康复，无后遗症。本文还概述了免疫功能正常儿童腺病毒中枢神经系统感染的已发表和未发表数据。
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