Department of Chemical Engineering, Texas Tech University, Lubbock, Texas, USA.
Department of Medical Oncology, Division of Hematology and Medical Oncology, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.
Biotechnol Bioeng. 2023 Jul;120(7):1707-1724. doi: 10.1002/bit.28388. Epub 2023 Mar 31.
Iron in blood cells has several physiological functions like transporting oxygen to cells and maintaining iron homeostasis. Iron is primarily contained in red blood cells (RBCs), but monocytes also store iron as these cells are responsible for the recycling of senescent RBCs. Iron also serves an important role related to the function of different leukocytes. In inflammation, iron homeostasis is dependent on cytokines derived from T cells and macrophages. Fluctuations of iron content in the body lead to different diseases. Iron deficiency, which is also known as anemia, hampers different physiological processes in the human body. On the other hand, genetic or acquired hemochromatosis ultimately results in iron overload and leads to the failure of different vital organs. Different diagnoses and treatments are developed for these kinds of disorders, but the majority are costly and suffer from side effects. To address this issue, magnetophoresis could be an attractive technology for the diagnosis (and in some cases treatment) of these pathologies due to the paramagnetic character of the cells containing iron. In this review, we discuss the main functions of iron in blood cells and iron-related diseases in humans and highlight the potential of magnetophoresis for diagnosing and treating some of these disorders.
铁在血细胞中有多种生理功能，如向细胞输送氧气和维持铁平衡。铁主要存在于红细胞（RBC）中，但单核细胞也储存铁，因为这些细胞负责衰老的 RBC 的回收。铁在与不同白细胞的功能相关的方面也起着重要作用。在炎症中，铁平衡依赖于 T 细胞和巨噬细胞产生的细胞因子。体内铁含量的波动会导致不同的疾病。铁缺乏，也称为贫血，会阻碍人体的不同生理过程。另一方面，遗传性或获得性血色病最终会导致铁过载，导致不同重要器官的衰竭。针对这些疾病制定了不同的诊断和治疗方法，但大多数方法都很昂贵，并且存在副作用。为了解决这个问题，由于含铁细胞的顺磁性，磁泳可能是一种有吸引力的诊断（在某些情况下是治疗）这些疾病的技术。在这篇综述中，我们讨论了铁在血细胞中的主要功能以及与人类相关的铁相关疾病，并强调了磁泳在诊断和治疗其中一些疾病方面的潜力。
