Laboratory of Immunopharmacology and Experimental Therapeutics, Division of Cancer Research, Regional Cancer Centre, Thiruvananthapuram, 695011, Kerala, India.
Curr Pharm Biotechnol. 2023;24(13):1613-1622. doi: 10.2174/1389201024666230331121328.
Mucositis is a debilitating and severe side effect of chemotherapy and radiotherapy. It is responsible for reducing the patient's quality of life and represents a significant economic burden in oncology. Currently, there is no definitive and definite treatment for this disease. Intracellular signalling pathways have provided excellent drug development resources, particularly cancer therapeutic development. In recent decades, active research has been conducted to describe the pathogenesis of mucositis and the role of nuclear factor-kappa B (NF-κB) signalling pathways in mucositis development. Insights into the mechanisms of mucositis are creating new approaches for effective targeted treatment and their success in clinical use. Several studies have concentrated on elucidating the functional significance of NF-kB activation and its signalling mechanisms in mucositis in recent decades. Also, evidence indicates that NF-κB is the primary node for the development and progression of mucositis. Its altered expression is associated with increased mucosal injury in mucositis. Hence, regulating the activation of NF-κB could be a powerful strategy for the clinical management of mucositis. Thus, this review examines the role of NF-κB as a potential therapeutic target for chemotherapy and radiation-induced mucositis therapy.
黏膜炎是化疗和放疗的一种使人虚弱和严重的副作用。它会降低患者的生活质量，并在肿瘤学方面带来巨大的经济负担。目前，这种疾病没有明确和确定的治疗方法。细胞内信号通路为药物开发提供了极好的资源，特别是癌症治疗药物的开发。在过去的几十年中，人们积极研究了黏膜炎的发病机制以及核因子-κB（NF-κB）信号通路在黏膜炎发展中的作用。对黏膜炎发病机制的深入了解正在为有效的靶向治疗创造新的方法，并有望在临床应用中取得成功。在过去的几十年中，有几项研究集中在阐明 NF-κB 激活及其信号机制在黏膜炎中的功能意义。此外，有证据表明 NF-κB 是黏膜炎发展和进展的主要节点。其表达的改变与黏膜炎中黏膜损伤的增加有关。因此，调节 NF-κB 的激活可能是治疗化疗和放疗引起的黏膜炎的一种有力策略。因此，本综述探讨了 NF-κB 作为化疗和放疗诱导的黏膜炎治疗的潜在治疗靶点的作用。
