Zhan Peng, Huang Shiming, Chen Daohua, Li Ying, Chen Dongfeng
Department of Bone and Joint Sports Medicine, Longyan First Affiliated Hospital of Fujian Medical University, No.105 Jiuyi North Road, Longyan, Fujian, 364000, China.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Jan 2. doi: 10.1007/s00210-024-03756-7.
Osteoarthritis (OA) is currently the most common degenerative joint disease in China and even worldwide and is the leading cause of disability in the elderly population. So far, due to an insufficient understanding of the pathogenesis and etiology of the disease, there is still no effective targeted treatment for early OA. Pro-inflammatory cytokine interleukin-1 is an important inflammatory mediator secreted in early OA, and IL-1β plays a crucial role in the pathogenesis of OA, affecting chondrocytes and the extracellular matrix of CARTILAGE. Echinatin has been used for years as a health supplement, retaining its antioxidant, anti-inflammatory, and autophagy-promoting effects. However, whether echinatin has inhibitory effects on OA is still unknown. In this study, we used an in vitro OA model of chondrocytes induced by IL-1β and an in vivo OA model of rats induced by anterior cruciate ligament transection (ACLT), and through experiments such as western blotting and IHC, we demonstrated that echinatin can be used as a novel drug for treating OA. Mechanistically, we found that echinatin inhibits the activity of chondrocytes induced by IL-1β through the NF-kB signaling pathway. This study can provide more effective treatment options for OA patients and further diagnostic and therapeutic methods for clinical treatment.
骨关节炎（OA）是目前中国乃至全球最常见的退行性关节疾病，是老年人群残疾的主要原因。迄今为止，由于对该疾病的发病机制和病因认识不足，早期OA仍然没有有效的靶向治疗方法。促炎细胞因子白细胞介素-1是早期OA分泌的一种重要炎症介质，IL-1β在OA发病机制中起关键作用，影响软骨细胞和软骨的细胞外基质。紫铆因多年来一直用作健康补充剂，具有抗氧化、抗炎和促进自噬的作用。然而，紫铆因对OA是否具有抑制作用仍不清楚。在本研究中，我们使用了IL-1β诱导的软骨细胞体外OA模型和前交叉韧带横断（ACLT）诱导的大鼠体内OA模型，并通过蛋白质免疫印迹和免疫组化等实验，证明紫铆因可作为一种治疗OA的新型药物。从机制上讲，我们发现紫铆因通过NF-κB信号通路抑制IL-1β诱导的软骨细胞活性。本研究可为OA患者提供更有效的治疗选择，并为临床治疗提供进一步的诊断和治疗方法。
