Department of Gastroenterology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Department of Chinese Medicine, Eye Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Phytother Res. 2023 May;37(5):2051-2066. doi: 10.1002/ptr.7806. Epub 2023 Mar 31.
Berberine is a plant extract widely used in clinical practice. This review aimed to summarize and to grade the available evidence on the association between berberine consumption and health-related outcomes. The PubMed, Cochrane Library, and Embase databases were searched for meta-analyses of randomized controlled trials (RCTs) assessing the efficacy and safety of berberine from inception to June 30, 2022. The AMSTAR-2 and GRADE system were used to assess the methodological quality and evidence level of the included meta-analyses. A total of 11 eligible meta-analyses were identified from 235 publications, which were published in peer-reviewed journals between 2013 and 2022. The results revealed that berberine significantly affects blood glucose levels, insulin resistance, blood lipids, body parameters and composition, inflammatory markers, colorectal adenomas, and Helicobacter pylori infections as compared to controls. Common side effects of berberine consumption include gastrointestinal symptoms, such as constipation and diarrhea. Berberine is a safe medicinal plant ingredient that improves various clinical outcomes; however, there is a need for improvement of methodological quality in published meta-analyses. Additionally, the clinical effects of berberine need to be confirmed in high-quality RCTs.
小檗碱是一种广泛应用于临床实践的植物提取物。本综述旨在总结和评估小檗碱摄入与健康相关结局之间关联的现有证据。从建库至 2022 年 6 月 30 日，我们检索了 PubMed、Cochrane Library 和 Embase 数据库中评估小檗碱疗效和安全性的随机对照试验（RCT）的荟萃分析。我们使用 AMSTAR-2 和 GRADE 系统评估纳入荟萃分析的方法学质量和证据水平。从 235 篇出版物中确定了 11 项符合条件的荟萃分析，这些出版物发表于 2013 年至 2022 年的同行评议期刊上。结果表明，与对照组相比，小檗碱显著影响血糖水平、胰岛素抵抗、血脂、身体参数和组成、炎症标志物、结直肠腺瘤和幽门螺杆菌感染。小檗碱的常见副作用包括便秘和腹泻等胃肠道症状。小檗碱是一种安全的药用植物成分，可改善各种临床结局；然而，需要提高已发表荟萃分析的方法学质量。此外，需要在高质量 RCT 中确认小檗碱的临床效果。
