Yadav Pooja, Quadri Khushi, Kadian Renu, Waziri Aafrin, Agrawal Pankaj, Alam Md Sabir
Department of Pharmacy Practice, SGT College of Pharmacy, SGT University, Gurgaon-Badli Road Chandu, Gurugram 122505, India.
Department of Pharmaceutics, SGT College of Pharmacy, SGT University, Gurgaon-Badli Road Chandu, Gurugram 122505, India.
ILIVER. 2024 Nov 8;3(4):100131. doi: 10.1016/j.iliver.2024.100131. eCollection 2024 Dec.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a widespread and potentially severe liver condition characterized by abnormal fat accumulation in the liver unrelated to alcohol consumption. According to the World Health Organization, MASLD is the most prevalent liver disease globally, it affects approximately 25% of the world's population, nearly two billion individuals. This staggering prevalence underscores the urgent need for effective and safe therapeutic approaches to address this escalating global health concern. Natural products have emerged as promising candidates for preventing and treating MASLD in recent years because of their diverse bioactive compounds and minimal side effects. Well-known natural products such as curcumin, resveratrol, green tea polyphenols, and silymarin exhibit notable hepatoprotective effects by influencing lipid metabolism, mitigating oxidative stress, and reducing inflammation. Ongoing research highlights the potential of phytochemicals from traditional medicinal plants, such as and , in ameliorating liver steatosis and fibrosis. These natural products demonstrate the capacity to impede fibrogenesis by interfering with hepatic stellate cell activation, which is pivotal in liver fibrosis development. Recent studies underscore the significance of natural products in modulating the gut-liver axis, where they restore balance to the gut microbiota and enhance intestinal barrier function, which slows the progression of MASLD. Moreover, advancements in nanotechnology facilitate the targeted delivery of natural product-derived compounds, which enhances their bioavailability and therapeutic efficacy. Harnessing the potency of natural products offers a promising avenue for developing novel, safer therapies for MASLD and addressing a critical global health concern with far-reaching implications for public well-being.
代谢功能障碍相关脂肪性肝病（MASLD）是一种广泛存在且可能严重的肝脏疾病，其特征是肝脏中出现与酒精摄入无关的异常脂肪堆积。根据世界卫生组织的数据，MASLD是全球最普遍的肝脏疾病，影响着全球约25%的人口，近20亿人。这一惊人的患病率凸显了迫切需要有效且安全的治疗方法来应对这一日益严重的全球健康问题。近年来，天然产物因其多样的生物活性化合物和最小的副作用，已成为预防和治疗MASLD的有前景的候选物。姜黄素、白藜芦醇、绿茶多酚和水飞蓟宾等著名天然产物通过影响脂质代谢、减轻氧化应激和减少炎症，展现出显著的肝脏保护作用。正在进行的研究突出了传统药用植物中的植物化学物质，如 和 ，在改善肝脏脂肪变性和纤维化方面的潜力。这些天然产物通过干扰肝星状细胞活化来证明其阻碍纤维生成的能力，而肝星状细胞活化在肝纤维化发展中至关重要。最近的研究强调了天然产物在调节肠-肝轴方面的重要性，它们在肠-肝轴中恢复肠道微生物群的平衡并增强肠道屏障功能，从而减缓MASLD的进展。此外，纳米技术的进步促进了天然产物衍生化合物的靶向递送，提高了它们的生物利用度和治疗效果。利用天然产物的效力为开发针对MASLD的新型、更安全的疗法提供了一条有前景的途径，并解决了一个对公众健康有深远影响的关键全球健康问题。
