Department of Pharmacy Services, Mayo Clinic Arizona, Phoenix, Arizona, USA.
Division of Public Health, Infectious Diseases, and Occupational Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Clin Infect Dis. 2023 Jul 26;77(2):167-173. doi: 10.1093/cid/ciad189.
Days of therapy (DOT) currently serve as the standard antimicrobial utilization metric. However, by assigning the same weight to each agent rather than accounting for differences in spectrum of activity, DOT ignore key differences between agents that are fundamental to infectious diseases and critical to antimicrobial stewardship. Spectrum scoring assigns numeric values to individual antibiotic agents to quantify their spectrum of activity, allowing for the normalization of antibiotic utilization data. When used in conjunction with traditional metrics, spectrum scores may offer further clarity to antibiotic utilization; however, issues related to development, application, and standardization of spectrum scores remain. Despite these challenges, the potential applications of spectrum scores are vast. Here, we summarize existing data and explore the future of spectrum scoring, including application to both data analysis and routine patient care, use in inpatient and outpatient settings, integration within the electronic medical record, and opportunities for future research.
治疗天数（DOT）目前是作为抗菌药物利用的标准衡量指标。然而，这种方法为每个药物分配相同的权重，而不考虑其作用谱的差异，从而忽略了药物之间的关键差异，而这些差异是感染性疾病的基础，对抗菌药物管理至关重要。药物谱评分通过为单个抗生素药物分配数值来量化其作用谱，从而使抗生素利用数据标准化。当与传统指标一起使用时，药物谱评分可以进一步阐明抗生素的利用情况；然而，药物谱评分的开发、应用和标准化仍然存在问题。尽管存在这些挑战，但药物谱评分的潜在应用非常广泛。在这里，我们总结了现有的数据，并探讨了药物谱评分的未来，包括在数据分析和常规患者护理中的应用、在住院和门诊环境中的应用、在电子病历中的整合以及未来研究的机会。
