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风险分层的住院患者青霉素过敏标签去除对后续抗菌谱指数和成本的影响。

Impacts of risk-stratified inpatient penicillin allergy label delabeling on subsequent antimicrobial spectrum index and costs.

作者信息

Staub Milner, Nelson George E, Byrge Kelly, Koo Grace, Nesbitt Whitney J, Stollings Joanna L, Zhang Minhua, Stone Cosby A

机构信息

Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

Medicine Service Line, Infectious Diseases Section, Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, USA.

出版信息

Antimicrob Steward Healthc Epidemiol. 2024 Oct 3;4(1):e160. doi: 10.1017/ash.2024.421. eCollection 2024.

DOI:10.1017/ash.2024.421
PMID:39371443
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11450671/
Abstract

Penicillin allergy delabeling may benefit antimicrobial stewardship (AS). Cost of initial penicillin treatments following risk-stratified inpatient delabeling were compared to two hypothetical treatment regimens if delabeling had not occurred: (1) AS-guided and (2) Common Treatment. Penicillin allergy delabeling improved antimicrobial spectrum index, was cost-neutral, and averted unnecessary penicillin desensitizations.

摘要

青霉素过敏标签去除可能有益于抗菌药物管理（AS）。将风险分层后的住院患者标签去除后初始青霉素治疗的成本，与如果未进行标签去除时的两种假设治疗方案进行比较：（1）AS指导方案和（2）常规治疗方案。青霉素过敏标签去除改善了抗菌谱指数，成本无变化，并避免了不必要的青霉素脱敏治疗。

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本文引用的文献

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JAMA Intern Med. 2023 Sep 1;183(9):944-952. doi: 10.1001/jamainternmed.2023.2986.
2
A Broad Spectrum of Possibilities: Spectrum Scores as a Unifying Metric of Antibiotic Utilization.广谱可能性：谱评分作为抗生素利用的统一度量标准。
Clin Infect Dis. 2023 Jul 26;77(2):167-173. doi: 10.1093/cid/ciad189.
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Infect Control Hosp Epidemiol. 2023 Apr;44(4):565-569. doi: 10.1017/ice.2022.151. Epub 2022 Jun 28.
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Low-risk penicillin allergy delabeling through a direct oral challenge in immunocompromised and/or multiple drug allergy labeled patients in a critical care setting.在重症监护环境中，通过对免疫功能低下和/或标记有多种药物过敏的患者进行直接口服激发试验，对低风险青霉素过敏进行去标签化处理。
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Testing Strategies and Predictors for Evaluating Immediate and Delayed Reactions to Cephalosporins.评估头孢菌素类药物即刻和延迟反应的检测策略和预测因素。
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Risk-stratified Management to Remove Low-Risk Penicillin Allergy Labels in the ICU.重症监护病房中基于风险分层的管理以去除低风险青霉素过敏标签
Am J Respir Crit Care Med. 2020 Jun 15;201(12):1572-1575. doi: 10.1164/rccm.202001-0089LE.
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