Department of Pharmaceutical Sciences, Albany College of Pharmacy and Health Science, Albany, NY 12208, USA.
Oncotarget. 2023 Mar 31;14:284-293. doi: 10.18632/oncotarget.28397.
Although many advances have been made in the treatment of breast cancer, for the triple negative breast cancer (TNBC) these therapies have not significantly increased overall survival. Tumor microenvironment (TME) plays an essential role to develop and control TNBC progression. Many preclinical and clinical studies are ongoing to treat patients with TNBC disease, but the effective therapies are currently not available. Here, we have reviewed recent progress in understanding of TNBC and advance in defining mechanisms of TNBC therapies and potential therapeutic strategies to overcome TNBC.
尽管在乳腺癌治疗方面已经取得了许多进展，但对于三阴性乳腺癌（TNBC），这些疗法并未显著提高总体生存率。肿瘤微环境（TME）在发展和控制 TNBC 进展方面发挥着重要作用。目前正在进行许多针对 TNBC 疾病患者的临床前和临床研究，但目前尚无有效的治疗方法。在这里，我们回顾了对 TNBC 的理解的最新进展，并介绍了定义 TNBC 治疗机制和潜在治疗策略的进展，以克服 TNBC。
