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新型纳米农药在白化大鼠肝脏和肺部的比较毒理学评价。

Comparative toxicological evaluations of novel forms nano-pesticides in liver and lung of albino rats.

机构信息

Cell Biology, Histology and Genetics Division, Department of Zoology, Faculty of Science, Beni-Suef University, P.O. BOX 62511, Beni-Suef, Egypt.

Molecular Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, P.O. Box 62511, Beni-Suef, Egypt.

出版信息

J Mol Histol. 2023 Apr;54(2):157-172. doi: 10.1007/s10735-023-10115-y. Epub 2023 Mar 31.

DOI:10.1007/s10735-023-10115-y
PMID:37000336
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10079706/
Abstract

Copper oxide Nanoparticles (CuONPs) are used in different agricultural applications. Large amounts of CuONPs cause organ dysfunction in animals. Our study aim to compare between the toxic effects of CuONanSphere (CuONSp) and CuONanoFlower (CuONF) as new nano-pesticides, determine a less toxic form when used in agricultural applications. To characterize CuONSp and CuONF, we used X-ray diffraction (XRD), Field emission scanning electron microscopy (SEM), and High resolution transmission electron microscopy (HRTEM) and Zeta-sizer device.18 adult male albino rats were divided into three groups (n = 6), (I) control group, (II) and (III) groups were given orally 50 mg/kg/day of CuONSp and CuONF 30 days respectively. CuONSp induced oxidant-antioxidant abnormalities, including an increase in malondialdhyde (MDA) and a decrease in glutathione (GSH) in comparison to CuONF-treated one. CuONSp induced an increase in liver enzymes activities compared to CuONF. Tumour necrosis factor-alfa (TNF-α) detected an increased in liver and lung compared to CuONF. However, histological examinations revealed changes in CuONSp group than CuONF group. Changes in immune-expressions of TNF-α, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kβ) and tumour suppressor gene (p53) were also more identified in CuONSp group than CuONF group. Ultrastructural studies of liver and lung tissues marked alternations were observed in CuONSp group than CuONF group. In conclusion, CuONSp induced biological alternation in liver and lung more than CuONF. So, CuONF is less toxic compared to CuONSp when used as nano-pesticide in agricultural applications.

摘要

氧化铜纳米粒子 (CuONPs) 被广泛应用于农业领域。大量的 CuONPs 会导致动物器官功能障碍。本研究旨在比较新型纳米农药 CuONanSphere (CuONSp) 和 CuONanoFlower (CuONF) 的毒性作用，确定在农业应用中更安全的形式。为了对 CuONSp 和 CuONF 进行特征描述，我们使用了 X 射线衍射 (XRD)、场发射扫描电子显微镜 (SEM)、高分辨率透射电子显微镜 (HRTEM) 和 Zeta-sizer 设备。18 只成年雄性白化大鼠被随机分为三组（n=6），（I）对照组，（II）和（III）组分别给予 50mg/kg/天的 CuONSp 和 CuONF 30 天。与 CuONF 处理的大鼠相比，CuONSp 导致氧化应激和抗氧化失衡，表现为丙二醛（MDA）增加，谷胱甘肽（GSH）减少。与 CuONF 相比，CuONSp 诱导肝脏酶活性增加。与 CuONF 相比，CuONSp 在肝脏和肺部检测到肿瘤坏死因子-α（TNF-α）增加。然而，组织学检查显示 CuONSp 组的变化比 CuONF 组更明显。CuONSp 组比 CuONF 组的 TNF-α、核因子 kappa 轻链增强子的 B 细胞（NF-kβ）和肿瘤抑制基因（p53）的免疫表达也发生了改变。肝、肺组织的超微结构研究发现，CuONSp 组的变化比 CuONF 组更明显。综上所述，CuONSp 对肝脏和肺部的生物影响比 CuONF 更明显。因此，在农业应用中作为纳米农药时，CuONF 比 CuONSp 的毒性更小。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e6/10079706/ff1a15d5102f/10735_2023_10115_Fig13_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e6/10079706/3341a98c81cb/10735_2023_10115_Fig3_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e6/10079706/88c3fa9f9899/10735_2023_10115_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e6/10079706/3148163065da/10735_2023_10115_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e6/10079706/3d6ee8b11ff0/10735_2023_10115_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e6/10079706/6bd8230d8761/10735_2023_10115_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e6/10079706/0319bfdad282/10735_2023_10115_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e6/10079706/da2df3263ee7/10735_2023_10115_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e6/10079706/6882e8d02dc7/10735_2023_10115_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e6/10079706/9d6452e4b73b/10735_2023_10115_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e6/10079706/ff1a15d5102f/10735_2023_10115_Fig13_HTML.jpg

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Copper Oxide Nanoparticle-Induced Acute Inflammatory Response and Injury in Murine Lung Is Ameliorated by Synthetic Secoisolariciresinol Diglucoside (LGM2605).氧化铜纳米颗粒诱导的小鼠肺部急性炎症反应和损伤可被合成开环异落叶松脂素二葡萄糖苷（LGM2605）所缓解。
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