Galelli A, le Garrec Y, Chedid L
Infect Immun. 1979 Feb;23(2):232-8. doi: 10.1128/iai.23.2.232-238.1979.
In a previous study we demonstrated that lipopolysaccharide failed to elicit nonspecific resistance in C3H/He lipopolysaccharide low-responder mice against Klebsiella infection in contrast to its activity in a closely related histocompatible high-responder subline, C3HeB/Fe. Complete restoration of lipopolysaccharide-induced protection against 10(5) Klebsiella was obtained in the present study by transferring bone marrow from high-responder mice to the highly deficient C3H/He mice. The ability of C3H/He mice to clear and destroy bacteria in 5 h was also transferred by C3HeB/Fe marrow cells. In contrast, when high-responder C3HeB/Fe mice were reconstituted with low-responder bone marrow, the clearance and destruction of K. pneumoniae were similar to what is observed in the high-responder strain, but survival was only temporary. Collectively, our data show that the failure of C3H/He mice to respond to lipopolysaccharide with nonspecific immunity is due to a defect in two types of bone-marrow-derived cells--radioresistant and radiosensitive.
在先前的一项研究中，我们证明，与在密切相关的组织相容性高反应性子系C3HeB/Fe中的活性相反，脂多糖未能在C3H/He脂多糖低反应性小鼠中引发针对克雷伯菌感染的非特异性抵抗力。在本研究中，通过将来自高反应性小鼠的骨髓移植到高度缺陷的C3H/He小鼠中，获得了脂多糖诱导的针对10⁵克雷伯菌的保护作用的完全恢复。C3HeB/Fe骨髓细胞还转移了C3H/He小鼠在5小时内清除和破坏细菌的能力。相反，当用低反应性骨髓重建高反应性C3HeB/Fe小鼠时，肺炎克雷伯菌的清除和破坏与在高反应性菌株中观察到的情况相似，但存活只是暂时的。总体而言，我们的数据表明，C3H/He小鼠无法通过非特异性免疫对脂多糖作出反应是由于两种骨髓来源的细胞——辐射抗性细胞和辐射敏感性细胞存在缺陷。
