革兰氏阴性菌对多粘菌素B九肽的敏感性。
Susceptibility of gram-negative bacteria to polymyxin B nonapeptide.
作者信息
Viljanen P, Vaara M
出版信息
Antimicrob Agents Chemother. 1984 Jun;25(6):701-5. doi: 10.1128/AAC.25.6.701.
Abstract
Subinhibitory concentrations of polymyxin B nonapeptide sensitized all 21 polymyxin-susceptible gram-negative bacterial strains studied to hydrophobic antibiotics such as fusidic acid, novobiocin, and erythromycin. The susceptibility increases were usually 30- to 300-fold. The strains included representatives of Escherichia coli with different O- and K-antigens, Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, Enterobacter agglomerans, Salmonella typhimurium, Acinetobacter calcoaceticus, Pseudomonas aeruginosa, and Pseudomonas maltophilia. In contrast, polymyxin-resistant strains (Proteus mirabilis, Proteus vulgaris, Morganella morganii, Providencia stuartii, and Serratia marcescens) were resistant to the action of polymyxin B nonapeptide.
摘要
多粘菌素B九肽的亚抑菌浓度使所研究的21株对多粘菌素敏感的革兰氏阴性菌对诸如夫西地酸、新生霉素和红霉素等疏水性抗生素敏感。敏感性增加通常为30至300倍。这些菌株包括具有不同O抗原和K抗原的大肠杆菌代表株、肺炎克雷伯菌、产酸克雷伯菌、阴沟肠杆菌、聚团肠杆菌、鼠伤寒沙门氏菌、醋酸钙不动杆菌、铜绿假单胞菌和嗜麦芽窄食单胞菌。相比之下，耐多粘菌素菌株（奇异变形杆菌、普通变形杆菌、摩根氏摩根菌、斯氏普罗威登斯菌和粘质沙雷氏菌）对多粘菌素B九肽的作用具有抗性。
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