卡介苗感染小鼠的内毒素诱导血清因子增强对感染的抵抗力
Enhancement of resistance to infections by endotoxin-induced serum factor from Mycobacterium bovis BCG-infected mice.
作者信息
Parant M A, Parant F J, Chedid L A
出版信息
Infect Immun. 1980 Jun;28(3):654-9. doi: 10.1128/iai.28.3.654-659.1980.
Abstract
Necrosis of a variety of transplanted murine tumors can be induced by serum from Mycobacterium bovis BCG-treated mice challenged with a lethal dose of endotoxin. Results reported here show that the tumor necrosis serum (TNS) enhances resistance to infections, protecting mice against two types of challenges, either with Klebsiella pneumoniae or with the intracellular parasite Listeria monocytogenes. Moreover, TNS activity was demonstrated in animals which are refractory to lipopolysaccharide and very susceptible to infections, such as 8-day-old mice and adult C3H/He mice. Protection passively transferred by TNS was not related to antibodies, since it was not decreased by absorption with homologous organisms.
摘要
用致死剂量内毒素攻击经牛分枝杆菌卡介苗处理的小鼠所获得的血清，可诱导多种移植性鼠肿瘤发生坏死。本文报道的结果表明，肿瘤坏死血清（TNS）可增强抗感染能力，保护小鼠抵御两种类型的攻击，即肺炎克雷伯菌或细胞内寄生虫单核细胞增生李斯特菌的攻击。此外，在对脂多糖耐受但极易感染的动物（如8日龄小鼠和成年C3H/He小鼠）体内也证实了TNS活性。TNS被动转移的保护作用与抗体无关，因为用同源生物体吸收后其作用并未减弱。
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