Hallberg L, Brune M, Rossander L
Hum Nutr Appl Nutr. 1986 Apr;40(2):97-113.
The effect of ascorbic acid on the absorption of non-heme iron was studied in 299 subjects. Different meals in which the non-heme iron was labelled with two different radio-iron isotopes were served with and without ascorbic acid to the same subject. Other meals containing foods with a known high content of ascorbic acid were also studied. Studies were also made giving different amounts of ascorbic acid with different meals. Marked differences in the enhancement of iron absorption were seen when ascorbic acid was given in different meals. It is suggested that ascorbic acid promotes iron absorption from the diet by reducing the negative effect on iron absorption of certain ligands such as phytates and tannins present in the diet. This interpretation is supported by observations that the most pronounced effects of ascorbic acid were found in meals with a high content of ligands known to inhibit iron absorption. Crystalline ascorbic acid and native ascorbic acid in foods appeared to have the same effect in promoting absorption of iron. The results indicate that ascorbic acid has a key physiologic role in facilitating the absorption of non-heme iron from the diet and that about 50 mg of the vitamin in each main meal is desirable for optimum effect.
在299名受试者中研究了抗坏血酸对非血红素铁吸收的影响。用两种不同的放射性铁同位素标记非血红素铁的不同膳食，在有和没有抗坏血酸的情况下提供给同一受试者。还研究了其他含有已知高抗坏血酸含量食物的膳食。也进行了在不同膳食中给予不同量抗坏血酸的研究。当在不同膳食中给予抗坏血酸时，观察到铁吸收增强方面存在显著差异。有人提出，抗坏血酸通过减少膳食中存在的某些配体（如植酸盐和单宁）对铁吸收的负面影响来促进饮食中铁的吸收。这一解释得到以下观察结果的支持：在含有已知抑制铁吸收的高含量配体的膳食中发现抗坏血酸的最显著作用。食物中的结晶抗坏血酸和天然抗坏血酸在促进铁吸收方面似乎具有相同的作用。结果表明，抗坏血酸在促进饮食中非血红素铁的吸收方面具有关键的生理作用，每餐约50毫克这种维生素可达到最佳效果。
