可穿戴设备指标与肿瘤学临床结局之间的关联：一项证据综合与荟萃分析的系统评价
The association between wearable device metrics and clinical outcomes in oncology: A systematic review with evidence synthesis and meta-analysis.
作者信息
Kos Milan, Brouwer Calvin G, van Laarhoven Hanneke W M, Hopman Maria T E, van Oijen Martijn G H, Buffart Laurien M
机构信息
Amsterdam UMC, University of Amsterdam, Medical Oncology, Cancer Center Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands; Cancer Center Amsterdam, Cancer Treatment and Quality of Life, Amsterdam, the Netherlands.
Department of Medical BioSciences, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, the Netherlands.
出版信息
Crit Rev Oncol Hematol. 2023 May;185:103979. doi: 10.1016/j.critrevonc.2023.103979. Epub 2023 Mar 30.
BACKGROUND
The emerging study of wearable devices (WDs) in patients with cancer provides opportunities to harness real-time patient data for predicting clinical outcomes. We conducted a systematic review with best evidence synthesis to examine the association between WD metrics and clinical outcomes in patients with cancer.
METHODS
MEDLINE and Embase were searched from inception until June 2022. Risk of bias assessment and best evidence synthesis were performed and, If possible, meta-analysis was conducted.
RESULTS
A total of 34 studies was included. We found moderate-to-strong evidence for associations between circadian rest-activity metrics and OS. Disrupted I<O was associated with increased hazard for death (HR 2.08; 95 %CI: 1.50-2.88). For most associations there was insufficient evidence due to lack of studies (n = 32) or inconsistent results (n = 14).
CONCLUSION
Meta-analysis was greatly hampered due to heterogeneity and different methodology used between studies. Studies primarily designed to investigate the association between WD metrics and clinical outcomes are warranted.
背景
针对癌症患者可穿戴设备（WDs）的新兴研究为利用实时患者数据预测临床结局提供了机会。我们进行了一项采用最佳证据综合法的系统评价，以研究WD指标与癌症患者临床结局之间的关联。
方法
检索MEDLINE和Embase数据库，检索时间从数据库建立至2022年6月。进行偏倚风险评估和最佳证据综合，如果可能，进行荟萃分析。
结果
共纳入34项研究。我们发现昼夜休息-活动指标与总生存期（OS）之间存在中度至强关联的证据。活动量低于摄入量（I<O）紊乱与死亡风险增加相关（风险比[HR] 2.08；95%置信区间[CI]：1.50 - 2.88）。由于缺乏研究（n = 32）或结果不一致（n = 14），对于大多数关联而言，证据不足。
结论
由于研究之间存在异质性和采用不同的方法，荟萃分析受到极大阻碍。有必要开展主要旨在研究WD指标与临床结局之间关联的研究。
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