Allen S S, Saxena K M
J Adolesc Health Care. 1986 May;7(3):198-201. doi: 10.1016/s0197-0070(86)80040-7.
Empty sella syndrome (ESS) is a condition in which the sella turcica is partially or completely filled with cerebrospinal fluid resulting in a displacement of the normal pituitary. The condition is more common and benign in adults, although associated endocrine abnormalities have been reported. In children and adolescents, the syndrome is rare (27 reported cases), and the clinical picture is much less benign, with an increase in familial incidence, associated skeletal disorders, and endocrine abnormalities. Definitive diagnosis can be made by CT scan of the head. Our case report is of an adolescent who appeared clinically to have growth retardation and normal endocrine function. The CT scan of the head was compatible with ESS. Further follow-up showed improved growth rate. Although our patient did not appear to have symptoms related to ESS, based on the literature we agree that this syndrome is much less benign in children and adolescents than in adults.
空蝶鞍综合征（ESS）是一种蝶鞍被脑脊液部分或完全填充，导致正常垂体移位的病症。该病症在成年人中更为常见且良性，尽管也有相关内分泌异常的报道。在儿童和青少年中，该综合征较为罕见（有27例报道病例），临床表现远非良性，家族发病率增加，伴有骨骼疾病和内分泌异常。通过头部CT扫描可做出明确诊断。我们的病例报告是关于一名临床上表现为生长发育迟缓且内分泌功能正常的青少年。头部CT扫描结果与空蝶鞍综合征相符。进一步随访显示生长速率有所改善。尽管我们的患者似乎没有与空蝶鞍综合征相关的症状，但基于文献，我们认同该综合征在儿童和青少年中比在成年人中良性程度更低。
