Batra R, Kuwada S, Maher V L
Hear Res. 1986;21(2):167-77. doi: 10.1016/0378-5955(86)90037-7.
Previous studies of the frequency-following response (FFR) in man suggest that it has multiple sources. Identification of these sources has been complicated by the use of tone bursts to evoke FFRs and the lack of precise methods to calculate their amplitude and latency. Tone bursts produce transient responses which confound measurements of the FFR. The use of continuous tones avoids this problem and the Fast Fourier Transform can be used to assess accurately and efficiently the presence, amplitude and phase angle of the FFR. In this study we systematically examined the frequency and intensity range over which FFRs to continuous tones could be evoked using FFRs to tone bursts for comparison. We then analyzed FFRs to continuous tones to determine the sources of this potential. FFRs to both stimuli have similar thresholds (65-90 dB SPL) and can be evoked by the same range of frequencies. Neurogenic FFRs in man occur only below 1000 Hz. The source for this potential has a latency of 8.2 +/- 0.1 ms (mean +/- SD) and is consistent with a midbrain source. At higher frequencies FFRs have a latency of less than 1 ms and are most likely cochlear microphonic. The small variation in the latency of the neurogenic FFR suggests this as a possible tool for assessing neurological disorders.
先前对人类频率跟随反应（FFR）的研究表明，其有多个来源。由于使用短音突发来诱发FFR以及缺乏精确计算其幅度和潜伏期的方法，这些来源的识别变得复杂。短音突发会产生瞬态反应，这会混淆FFR的测量。使用连续音调可避免此问题，并且快速傅里叶变换可用于准确且高效地评估FFR的存在、幅度和相位角。在本研究中，我们系统地研究了使用短音突发诱发FFR进行比较时，能诱发连续音调FFR的频率和强度范围。然后，我们分析了连续音调的FFR以确定这种电位的来源。两种刺激的FFR具有相似的阈值（65 - 90 dB SPL），并且可由相同的频率范围诱发。人类的神经源性FFR仅在1000 Hz以下出现。这种电位的来源潜伏期为8.2 +/- 0.1 ms（平均值 +/- 标准差），与中脑来源一致。在较高频率下，FFR的潜伏期小于1 ms，很可能是耳蜗微音电位。神经源性FFR潜伏期的微小变化表明其可能作为评估神经系统疾病的一种工具。
