Yang Xuezhou, Ning Kaiting, Wang Dong-En, Xu Huiyun
Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi, China.
Stem Cells Dev. 2023 Jul;32(13-14):379-386. doi: 10.1089/scd.2023.0019. Epub 2023 May 2.
There has been an upsurge of interest in the bone marrow mesenchymal stem cell (BMSC) mitochondrial transfer as a potential therapeutic innovation in organ injury repair. Previous research mainly focused on its transfer routes and therapeutic effects. However, its intrinsic mechanism has not been well deciphered. The current research status needs to be summarized for the clarification of future research direction. Therefore, we review the recent significant progress in the application of BMSC mitochondrial transfer in organ injury repair. The transfer routes and effects are summarized, and some suggestions on the future research direction are provided.
骨髓间充质干细胞（BMSC）线粒体转移作为器官损伤修复中一种潜在的治疗创新方法，引起了人们极大的兴趣。以往的研究主要集中在其转移途径和治疗效果上。然而，其内在机制尚未得到很好的阐释。需要总结当前的研究现状，以明确未来的研究方向。因此，我们综述了BMSC线粒体转移在器官损伤修复应用中的最新重大进展。总结了转移途径和效果，并对未来的研究方向提出了一些建议。
