Department of Microbiology and Virology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Microb Pathog. 2023 Jun;179:106087. doi: 10.1016/j.micpath.2023.106087. Epub 2023 Mar 30.
This study aimed to investigate the prevalence and any potential association between Epstein-Barr virus (EBV) infection and colorectal cancer (CRC).
A systematic literature search was performed by finding relevant cross-sectional and case-control studies from main online databases. Heterogeneity, odds ratio (OR), and corresponding 95% confidence interval (CI) were applied to all studies through meta-analysis and forest plots. The analysis was performed using STATA Software v.14.1.
Twenty-three articles were included in the meta-analysis, eight of them were case/control and 15 were cross-sectional. The pooled prevalence of EBV among 1954 CRC patients was 18% (95% CI: 12%-26%; I = 93.14%). Furthermore, in geographical regions, the highest and lowest prevalence of EBV was observed in South America 30% (95% CI: 18%-43%) and Africa 0% (95% CI: 0%-5%), respectively. An association was found between EBV infection and CRC [OR = 3.4 (95% CI (1.13-10.27); I = 72.3%)].
EBV infection is associated with CRC and can be considered a potential risk factor for the development of CRC. Although the exact molecular mechanism of EBV infection in the development of CRC is still unknown, it seems that latent infection by EBV, intestinal damage, and inflammation can be important factors in the induction of CRC.
本研究旨在调查 Epstein-Barr 病毒（EBV）感染与结直肠癌（CRC）之间的流行情况及其可能的关联。
通过在主要在线数据库中查找相关的横断面和病例对照研究，进行系统的文献检索。通过荟萃分析和森林图，对所有研究应用异质性、优势比（OR）和相应的 95%置信区间（CI）。分析使用 STATA 软件 v.14.1 进行。
23 篇文章被纳入荟萃分析，其中 8 篇为病例对照研究，15 篇为横断面研究。1954 例 CRC 患者中 EBV 的总流行率为 18%（95%CI：12%-26%；I=93.14%）。此外，在地理位置上，EBV 流行率最高的是南美洲，为 30%（95%CI：18%-43%），最低的是非洲，为 0%（95%CI：0%-5%）。发现 EBV 感染与 CRC 之间存在关联[OR=3.4（95%CI（1.13-10.27）；I=72.3%）]。
EBV 感染与 CRC 相关，可以被认为是 CRC 发病的潜在危险因素。尽管 EBV 感染在 CRC 发展中的确切分子机制尚不清楚，但 EBV 潜伏感染、肠道损伤和炎症似乎是 CRC 发生的重要因素。
