Ibeanu Gordon C, Rowaiye Adekunle B, Okoli Joy C, Eze Daniel U
Department of Pharmaceutical Sciences, North Carolina Central University, Durham, NC, 27707, USA.
Department of Agricultural Biotechnology, National Biotechnology Development Agency, Abuja, Nigeria.
Immunotargets Ther. 2024 Dec 13;13:749-774. doi: 10.2147/ITT.S486731. eCollection 2024.
Colorectal cancer (CRC) is the third most prevalent cancer worldwide, with numerous risk factors contributing to its development. Recent research has illuminated the significant role of the gut microbiota in CRC pathogenesis, identifying various microbial antigens as potential targets for vaccine development.
This review aimed at exploring the potential sources of microbial antigens that could be harnessed to create effective CRC vaccines and understand the role of microbiome-CRC interactions in carcinogenesis.
A comprehensive search of original research and review articles on the pathological links between key microbial candidates, particularly those more prevalent in CRC tissues, was conducted. This involved extensive use of the PubMed and Medline databases, as well as the Google Scholar search engine, utilizing pertinent keywords. A total of one hundred and forty-three relevant articles in English, mostly published between 2018 and 2024, were selected.
Numerous microbes, particularly bacteria and viruses, are significantly overrepresented in CRC tissues and have been shown to promote tumorigenesis by inducing inflammation and modulating the immune system. This makes them promising candidates for antigens in the development of CRC vaccines.
The selection of microbial antigens focuses on their capacity to trigger a strong immune response and their link to tumor presence and progression. Identifying and validating these antigens through preclinical testing is essential in developing a CRC vaccine.
结直肠癌（CRC）是全球第三大常见癌症，其发生有众多风险因素。最近的研究揭示了肠道微生物群在CRC发病机制中的重要作用，确定了各种微生物抗原作为疫苗开发的潜在靶点。
本综述旨在探索可用于研发有效CRC疫苗的微生物抗原潜在来源，并了解微生物群与CRC相互作用在致癌过程中的作用。
对有关关键微生物候选物（特别是在CRC组织中更普遍的那些）之间病理联系的原始研究和综述文章进行全面检索。这涉及广泛使用PubMed和Medline数据库以及谷歌学术搜索引擎，使用相关关键词。总共选择了143篇英文相关文章，大多发表于2018年至2024年之间。
许多微生物，特别是细菌和病毒，在CRC组织中显著富集，并已显示通过诱导炎症和调节免疫系统来促进肿瘤发生。这使它们成为CRC疫苗开发中有前景的抗原候选物。
微生物抗原的选择侧重于其引发强烈免疫反应的能力及其与肿瘤存在和进展的联系。通过临床前测试识别和验证这些抗原对于开发CRC疫苗至关重要。
