Department of Clinical Laboratory Medicine, Shizuoka General Hospital, 4-27-1, Kitaandou, Aoi-ku, Shizuoka, 420-8527, Japan.
Department of Pharmacy, Shizuoka General Hospital, 4-27-1, Kitaandou, Aoi-ku, Shizuoka, 420-8527, Japan.
J Infect Chemother. 2023 Jul;29(7):707-709. doi: 10.1016/j.jiac.2023.03.017. Epub 2023 Mar 31.
Filifactor alocis, an anaerobic Gram-positive rod, has garnered interest from its association with periodontal disease. Extraoral infections by F. alocis are rare; only seven cases have been reported. We report the first case in which we identified F. alocis as one of the causative organisms of a deep neck abscess. A 71-year-old male on hemodialysis came to our hospital with a fever and left buccal pain. The patient's left neck was swollen, and contrast-enhanced computed tomography showed an abscess with gas extending from the left cheek to the deep neck. We diagnosed the patient with a deep neck abscess and performed an urgent neck drainage. We isolated F. alocis, Eggerthia catenaformis, Parvimonas micra, and Streptococcus constellatus in the abscess and identified them using matrix-assisted laser desorption ionization-time of flight mass spectrometry. Blood cultures were negative. We initiated treatment with piperacillin-tazobactam and vancomycin. The patient improved but developed a hemorrhagic duodenal ulcer on the third day of admission. We attempted endoscopic hemostasis, but the patient's bleeding continued. Ultimately, he died of the duodenal ulcer hemorrhage on the sixth day of admission. This is the first case of F. alocis detected in a deep neck abscess.
嗜二氧化碳纤维菌,一种厌氧革兰阳性杆菌,因其与牙周病有关而受到关注。嗜二氧化碳纤维菌的口腔外感染很少见;仅报告了 7 例病例。我们报告了首例鉴定为嗜二氧化碳纤维菌引起深部颈脓肿的病例。一名 71 岁男性,正在接受血液透析,因发热和左侧颊部疼痛来我院就诊。患者左侧颈部肿胀,增强 CT 显示有脓肿,伴有气体从左侧脸颊延伸至深部颈部。我们诊断为深部颈脓肿,并进行了紧急颈部引流。我们从脓肿中分离出嗜二氧化碳纤维菌、卡特恩氏菌、小韦荣球菌和星座链球菌,并使用基质辅助激光解吸电离飞行时间质谱法进行了鉴定。血培养为阴性。我们开始使用哌拉西林他唑巴坦和万古霉素进行治疗。患者病情好转,但在入院第三天出现了出血性十二指肠溃疡。我们尝试了内镜止血,但患者的出血持续存在。最终,他在入院第六天因十二指肠溃疡出血而死亡。这是首例在深部颈脓肿中检测到嗜二氧化碳纤维菌的病例。