血小板单采术：六种不同方案的比较研究

Plateletpheresis: a comparative study of six different protocols.

作者信息

Puig L, Mazzara R, Gelabert A, Castillo R

出版信息

J Clin Apher. 1986;3(2):129-32. doi: 10.1002/jca.2920030210.

DOI:10.1002/jca.2920030210

Abstract

Six different protocols were employed in 710 plateletpheresis employing Haemonetics 30, Fenwal CS-3000, IBM 2997 dual stage channel, IBM 2997 single-stage channel, and Haemonetics V-50 "surge pump" method. When Haemonetics 30 and IBM 2997 single-stage channel procedures were used, 5.4 to 5.9 X 10(11) platelets were collected with significant leukocyte contamination (10.8 to 11.6 X 10(9)). With Fenwal CS-3000, dual-stage channel of IBM 2997 and Haemonetics V-50 "surge pump" there was less leukocyte contamination in concentrates (0.3 to 0.9 X 10(9)) as well as a lower platelet yield (3.4 to 4.3 X 10(11)). No difference in yield was observed when plateletpheresis was performed with ACD-A or ACD-B employing the single-stage channel of IBM 2997. Paresthesias was the most frequently seen side effect in donors, with a higher incidence when using ACD-A and IBM 2997.

摘要

在使用Haemonetics 30、Fenwal CS - 3000、IBM 2997双级通道、IBM 2997单级通道以及Haemonetics V - 50“蠕动泵”方法的710次血小板单采术中采用了六种不同的方案。当使用Haemonetics 30和IBM 2997单级通道程序时，采集到5.4至5.9×10¹¹个血小板，但有大量白细胞污染（10.8至11.6×10⁹）。使用Fenwal CS - 3000、IBM 2997双级通道以及Haemonetics V - 50“蠕动泵”时，浓缩物中的白细胞污染较少（0.3至0.9×10⁹），但血小板产量较低（3.4至4.3×10¹¹）。当使用IBM 2997单级通道采用ACD - A或ACD - B进行血小板单采时，未观察到产量差异。感觉异常是供者中最常见的副作用，在使用ACD - A和IBM 2997时发生率更高。