Wang Rong, Wang Lulu, Zhang Manli, Guo Yadi, Zhang Jing, Ma Guoxu
College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
College of Medicine, Changchun University of Science and Technology, Changchun 130600, China.
Chin J Nat Med. 2023 Mar;21(3):226-232. doi: 10.1016/S1875-5364(23)60423-6.
Five new spirostanol saponins (1-5) and seven known compounds (6-12) were isolated from the n-butanol fraction of 75% ethanol extract of Allii Macrostemonis Bulbus. The identification and structural elucidation of all the isolates were performed through extensive 1D and 2D NMR experiments, HR-ESI-MS data analysis and comparisons with literature values. Antioxidant evaluation showed that compounds 6-11 exhibited certain scavenging effects on ABTS radical, where compounds 6, 7 and 11 had IC values of 0.208, 0.057 and 0.014 mg·mL, respectively.
从薤白75%乙醇提取物的正丁醇部位分离得到5个新的螺旋甾烷醇皂苷（1-5）和7个已知化合物（6-12）。通过广泛的一维和二维核磁共振实验、高分辨电喷雾电离质谱数据分析以及与文献值比较，对所有分离物进行了鉴定和结构解析。抗氧化活性评价表明，化合物6-11对ABTS自由基具有一定的清除作用，其中化合物6、7和11的半数抑制浓度（IC）分别为0.208、0.057和0.014 mg·mL。
