Cardiovascular Imaging Program, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Cardiovascular Imaging Program, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Cardiol Clin. 2023 May;41(2):185-195. doi: 10.1016/j.ccl.2023.01.007. Epub 2023 Feb 21.
Myocardial blood flow (MBF) and flow reserve (MFR) measurements by PET/computed tomography provide incremental diagnostic and prognostic information over traditional quantification of ischemia and scar by myocardial perfusion imaging. A normal stress MBF and MFR (>2.0) have a very high negative predictive value for excluding high-risk obstructive coronary artery disease (CAD). These flow measurements are also used for surveillance of coronary allograft vasculopathy after heart transplantation. A global normal MFR (>2.0) identifies patients at lower clinical risk, whereas a severely reduced MFR (<1.5) identifies patients at high risk for adverse events, even among patients without regional perfusion abnormalities.
正电子发射断层扫描/计算机断层扫描（PET/CT）心肌血流（MBF）和血流储备（MFR）测量比心肌灌注成像传统的缺血和瘢痕量化提供了更多的诊断和预后信息。正常应激 MBF 和 MFR（>2.0）对排除高危阻塞性冠状动脉疾病（CAD）具有非常高的阴性预测值。这些流量测量也用于心脏移植后冠状动脉移植血管病的监测。全球正常 MFR（>2.0）可识别临床风险较低的患者，而严重降低的 MFR（<1.5）可识别发生不良事件风险较高的患者，即使在没有区域性灌注异常的患者中也是如此。
