Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Medical Imaging, Montreal Heart Institute, Montreal, Quebec, Canada.
Curr Cardiol Rep. 2019 Feb 28;21(3):11. doi: 10.1007/s11886-019-1096-x.
The aim of this review is to provide an update on quantification of myocardial blood flow (MBF) with positron emission tomography (PET) imaging. Technical and clinical aspects of flow quantification with PET are reviewed.
The diagnostic and prognostic values of myocardial flow quantification have been established in numerous studies and in various populations. MBF quantification has also shown itself to be particularly useful in the assessment of coronary microvascular dysfunction and in evaluation of cardiac allograft vasculopathy. Overall, myocardial flow reserve (MFR) and hyperemic MBF can lead to improved risk stratification by providing information complementary to that of other markers of disease severity, such as fractional flow reserve. Flow quantification enhances MPI's ability to detect both significant epicardial disease and microvascular dysfunction. With recent technological and methodological advances, flow quantification with PET is no longer restricted to cyclotron-equipped academic centers.
本综述旨在提供正电子发射断层扫描（PET）成像测量心肌血流（MBF）的最新进展。本文回顾了 PET 血流定量的技术和临床方面。
大量研究和不同人群证实了心肌血流定量的诊断和预后价值。MBF 定量在评估冠状动脉微血管功能障碍和评估心脏移植血管病方面也显示出特别有用。总的来说，心肌血流储备（MFR）和充血性 MBF 通过提供与其他疾病严重程度标志物（如血流储备分数）互补的信息，可改善风险分层。血流定量增强了 MPI 检测明显的冠状动脉疾病和微血管功能障碍的能力。随着最近技术和方法的进步，PET 血流定量已不再局限于配备回旋加速器的学术中心。
