Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul 02841, Republic of Korea; Department of Microbiology, Institute for Viral Diseases, Vaccine Innovation Center, College of Medicine, Korea University, Seoul, Republic of Korea.
Vaccine. 2023 Apr 24;41(17):2769-2772. doi: 10.1016/j.vaccine.2023.03.044. Epub 2023 Mar 27.
Previous studies have shown that fully vaccinated patients with SARS-CoV-2 Delta variants has shorter viable viral shedding period compared to unvaccinated or partially vaccinated patients. However, data about effects of vaccination against the viable viral shedding period in patients with SARS-CoV-2 Omicron variants were limited. We compared the viable viral shedding period of SARS-CoV-2 omicron variant regard to vaccination status. Saliva samples were obtained daily from patients with SARS-CoV-2 Omicron variant, and genomic assessments and virus culture was performed to those samples. We found no difference in viable viral shedding period between fully vaccinated and not or partially vaccinated, nor between 1st boostered vs non-boostered patients with SARS-CoV-2 Omicron variant.
先前的研究表明，与未接种疫苗或部分接种疫苗的患者相比，接种过疫苗的 SARS-CoV-2 Delta 变异株患者的活病毒脱落期更短。然而，关于接种疫苗对 SARS-CoV-2 奥密克戎变异株患者活病毒脱落期影响的数据有限。我们比较了接种疫苗对 SARS-CoV-2 奥密克戎变异株活病毒脱落期的影响。从感染 SARS-CoV-2 奥密克戎变异株的患者中每天采集唾液样本，并对这些样本进行基因组评估和病毒培养。我们发现，接种过疫苗和未接种或部分接种疫苗的患者之间，以及接种过 1 针加强针和未接种加强针的患者之间，活病毒脱落期没有差异。
