Department of Otolaryngology-Head and Neck Surgery, Beijing Anzhen Hospital, Capital Medical University, 2 Anzhen Road, Beijing, 100029, China.
Department of Otolaryngology-Head and Neck Surgery, Xuanwu Hospital Capital Medical University, 45 Changchun Street, Beijing, 100053, China.
Eur Arch Otorhinolaryngol. 2023 Aug;280(8):3737-3743. doi: 10.1007/s00405-023-07932-y. Epub 2023 Apr 1.
To investigate the factors influencing the volume of the olfactory bulb (OB) in patients with post-viral olfactory dysfunction (PVOD).
We collected 92 olfactory bulb volumes from patients with PVOD who underwent a sinus computed tomographic and magnetic resonance imaging (MRI) scan of the head and collected clinical information including gender, age, disease course, minimal cross-sectional area, nasal airway resistance, and olfactory function. OB volume was measured in MRI and the scans were evaluated according to the Lund-Mackay (LM) scoring system.
Male patients with PVOD had a larger OB volume (β = 0.284, P < 0.05). OB volume was smaller in patients with a longer course of olfactory dysfunction (β = - 0.254, P < 0.05). According to the LM scoring system, patients with a higher anterior ethmoidal sinus score had smaller OB volume (β = - 0.476, P < 0.05).
The study revealed that gender, disease course, and the score of anterior ethmoidal sinusitis can affect the OB volume in patients with PVOD.
研究影响病毒性嗅觉功能障碍（PVOD）患者嗅球（OB）体积的因素。
我们收集了 92 例经鼻窦计算机断层扫描和头部磁共振成像（MRI）检查的 PVOD 患者的嗅球体积，并收集了包括性别、年龄、病程、最小横截面积、鼻腔气道阻力和嗅觉功能在内的临床信息。在 MRI 中测量 OB 体积，并根据 Lund-Mackay（LM）评分系统对扫描进行评估。
PVOD 男性患者的 OB 体积较大（β=0.284，P<0.05）。嗅觉功能障碍病程较长的患者 OB 体积较小（β=-0.254，P<0.05）。根据 LM 评分系统，前筛窦评分较高的患者 OB 体积较小（β=-0.476，P<0.05）。
本研究表明，性别、病程和前筛窦炎评分可影响 PVOD 患者的 OB 体积。
