Mechanobiology and Regenerative Medicine Laboratory, Bioengineering College, Chongqing University, Chongqing, 400044, People's Republic of China.
State Key Laboratory of New Textile Materials and Advanced Processing Technologies, Wuhan Textile University, No. 1 Sunshine Avenue, Jiangxia District, Wuhan, Hubei Province, 430200, People's Republic of China.
J Biol Phys. 2023 Sep;49(3):283-307. doi: 10.1007/s10867-023-09633-3. Epub 2023 Apr 1.
The occurrence and development of tumors depend on a complex regulation by not only biochemical cues, but also biomechanical factors in tumor microenvironment. With the development of epigenetic theory, the regulation of biomechanical stimulation on tumor progress genetically is not enough to fully illustrate the mechanism of tumorigenesis. However, biomechanical regulation on tumor progress epigenetically is still in its infancy. Therefore, it is particularly important to integrate the existing relevant researches and develop the potential exploration. This work sorted out the existing researches on the regulation of tumor by biomechanical factors through epigenetic means, which contains summarizing the tumor epigenetic regulatory mode by biomechanical factors, exhibiting the influence of epigenetic regulation under mechanical stimulation, illustrating its existing applications, and prospecting the potential. This review aims to display the relevant knowledge through integrating the existing studies on epigenetic regulation in tumorigenesis under mechanical stimulation so as to provide theoretical basis and new ideas for potential follow-up research and clinical applications. Mechanical factors under physiological conditions stimulate the tumor progress through epigenetic ways, and new strategies are expected to be found with the development of epidrugs and related delivery systems.
肿瘤的发生和发展不仅取决于生化线索的复杂调控，还取决于肿瘤微环境中的生物力学因素。随着表观遗传理论的发展，生物力学刺激对肿瘤进展的遗传调控还不足以充分说明肿瘤发生的机制。然而，生物力学对肿瘤进展的表观遗传调控仍处于起步阶段。因此，整合现有相关研究并开发其潜在的探索尤为重要。本工作通过表观遗传学手段梳理了生物力学因素对肿瘤的调控作用的现有研究，其中包括总结生物力学因素对肿瘤的表观遗传调控模式，展示机械刺激下的表观遗传调控的影响，阐述其现有的应用，并展望其潜在的应用。本综述旨在通过整合机械刺激下肿瘤发生的表观遗传调控的现有研究，展示相关知识，为潜在的后续研究和临床应用提供理论基础和新的思路。生理条件下的机械因素通过表观遗传途径刺激肿瘤进展，有望随着表型药物和相关递药系统的发展找到新的策略。
