Dolatshahi Mahsa, Sanjari Moghaddam Hossein, Saberi Parastoo, Mohammadi Soheil, Aarabi Mohammad Hadi
NeuroImaging Laboratories, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, United States; NeuroImaging Network (NIN), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Diabetes Res Clin Pract. 2023 Nov;205:110645. doi: 10.1016/j.diabres.2023.110645. Epub 2023 Mar 31.
Type 1 diabetes mellitus (T1DM) is a chronic childhood disease with potentially persistent CNS disruptions. In this study, we aimed to systematically review diffusion tensor imaging studies in patients with T1DM to understand the microstructural effects of this entity on individuals' brains METHODS: We performed a systematic search and reviewed the studies to include the DTI studies in individuals with T1DM. The data for the relevant studies were extracted and a qualitative synthesis was performed.
A total of 19 studies were included, most of which showed reduced FA widespread in optic radiation, corona radiate, and corpus callosum, as well as other frontal, parietal, and temporal regions in the adult population, while most of the studies in the juvenile patients showed non-significant differences or a non-persistent pattern of changes. Also, reduced AD and MD in individuals with T1DM compared to controls and non-significant differences in RD were noted in the majority of studies. Microstructural alterations were associated with clinical profile, including age, hyperglycemia, diabetic ketoacidosis and cognitive performance.
T1DM is associated with microstructural brain alterations including reduced FA, MD, and AD in widespread brain regions, especially in association with glycemic fluctuations and in adult age.
1型糖尿病（T1DM）是一种慢性儿童疾病，可能会导致持续性的中枢神经系统破坏。在本研究中，我们旨在系统回顾T1DM患者的扩散张量成像研究，以了解该疾病对个体大脑的微观结构影响。方法：我们进行了系统检索，并对研究进行了回顾，纳入了T1DM个体的DTI研究。提取了相关研究的数据并进行了定性综合分析。
共纳入19项研究，其中大多数研究表明，在成年人群中，视辐射、放射冠和胼胝体以及其他额叶、顶叶和颞叶区域的FA普遍降低，而大多数针对青少年患者的研究显示差异不显著或变化模式不持久。此外，大多数研究指出，与对照组相比，T1DM个体的AD和MD降低，而RD差异不显著。微观结构改变与临床特征相关，包括年龄、高血糖、糖尿病酮症酸中毒和认知表现。
T1DM与大脑微观结构改变有关，包括广泛脑区的FA、MD和AD降低，尤其是与血糖波动及成年期相关。
