Aragão Alexandre A B, Bouskela Eliete, Bottino Daniel A
CClinical and Experimental Research Laboratory on Vascular Biology (BioVasc),Biomedical Center, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
CClinical and Experimental Research Laboratory on Vascular Biology (BioVasc),Biomedical Center, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
J Clin Densitom. 2023 Apr-Jun;26(2):101365. doi: 10.1016/j.jocd.2023.03.004. Epub 2023 Mar 11.
To evaluate body composition, especially visceral adipose tissue (VAT), by dual-energy x-ray absorptiometry (DXA) and its relation to endothelial function investigated by venous occlusion plethysmography (VOP) and ultrasensitive C-reactive protein (hsCRP).
This is a cross sectional study in adults of both sexes divided into group 1 (BMI, 20-24.9, n=30), group 2 (BMI, 25-29.9, n=22), group 3 (BMI, 30-34.9, n=27) and group 4 (BMI, 35-39.9, n=22). VAT was analyzed, among other parameters of adiposity, by DXA Lunar iDXA, and co-related to endothelial function, anthropometric evaluation, cardiometabolic variables and hsCRP. For statistical analysis, tests of comparison between groups and correlation were performed using the software SPSS version 25.
Inverse correlation of TFT (total fat mass), % RFM (regional fat mass), FMI (fat mass index) and VAT were identified with increment of arterial blood flow in VOP, except the decrease of the latter, with increase of BMI, adiposity indexes, especially VAT, between groups. hsCRP values showed a direct correlation with progression of adiposity and VAT, between groups.
VAT progression, by DXA analysis, was associated with a decline in endothelial function and increase of inflammation, demonstrating potential use in early identification of individuals with cardiovascular risk (CVR).
通过双能X线吸收法（DXA）评估身体成分，尤其是内脏脂肪组织（VAT），并研究其与通过静脉阻塞体积描记法（VOP）和超敏C反应蛋白（hsCRP）所检测的内皮功能之间的关系。
这是一项针对成年男女的横断面研究，分为第1组（BMI为20 - 24.9，n = 30）、第2组（BMI为25 - 29.9，n = 22）、第3组（BMI为30 - 34.9，n = 27）和第4组（BMI为35 - 39.9，n = 22）。除了其他肥胖参数外，通过DXA Lunar iDXA分析VAT，并将其与内皮功能、人体测量评估、心脏代谢变量和hsCRP进行相关性分析。对于统计分析，使用SPSS 25版软件进行组间比较测试和相关性分析。
除了随着BMI增加，组间肥胖指数尤其是VAT增加时VAT减少外，在VOP中，总脂肪量（TFT）、区域脂肪量百分比（%RFM）、脂肪量指数（FMI）和VAT与动脉血流增加呈负相关。组间hsCRP值与肥胖和VAT的进展呈正相关。
通过DXA分析，VAT进展与内皮功能下降和炎症增加相关，表明其在早期识别心血管风险（CVR）个体方面具有潜在用途。
