Department of Radiation Oncology, University of Florida College of Medicine, 2015 North Jefferson Street, Jacksonville, FL 32206, USA.
Department of Radiation Oncology, University of Florida College of Medicine, 2015 North Jefferson Street, Jacksonville, FL 32206, USA.
Oral Maxillofac Surg Clin North Am. 2023 Aug;35(3):469-484. doi: 10.1016/j.coms.2023.02.003. Epub 2023 Mar 31.
Proton therapy (PT) is a form of highly conformal external-beam radiotherapy used to mitigate acute and late effects following radiotherapy. Indications for treatment include both benign and malignant skull-base and central nervous system pathologies. Studies have demonstrated that PT shows promising results in minimizing neurocognitive decline and reducing second malignancies with low rates of central nervous system necrosis. Future directions and advances in biologic optimization may provide additional benefits beyond the physical properties of particle dosimetry.
质子治疗（PT）是一种高度适形的外照射放疗，用于减轻放疗后的急性和晚期效应。治疗的适应证包括良性和恶性颅底和中枢神经系统病变。研究表明，PT 具有降低神经认知下降和减少第二恶性肿瘤的潜力，同时中枢神经系统坏死的发生率较低。未来在生物学优化方面的发展可能会提供超越粒子剂量学物理特性的额外益处。
