Department of Physical Therapy and Rehabilitation Science, College of Health Sciences, QU Health, Qatar University, Doha, Qatar.
NeuroRehabilitation. 2023;52(3):387-402. doi: 10.3233/NRE-220264.
Anxiety is a prominent disabling non-motor neuropsychiatric complication of Parkinson's disease (PD). Pharmacological treatments for PD and anxiety have drug interactions and negative side effects. Therefore, non-pharmacological interventions such as exercise has been proposed to reduce anxiety in people with PD (PwP).
This systematic review aimed to explore the relationship between physical exercise and anxiety in PwP.
Four databases (PubMed, Embase, Scopus, Ebscohost) were searched without date restrictions. English randomized control trials (RCT) including adults with PD, exposed to physical exercise interventions with anxiety as an outcome variable, were included. Quality was assessed by means of an adapted 9-point PEDro scale.
Five of the identified 5547 studies met the inclusion criteria. Sample size ranged between 11-152 participants, totaling 328 participants with majority being male. PD stage ranged from early to moderate, with disease duration ranged between 2.9 and 8.0 years. All studies measured anxiety at baseline and post-intervention. On average studies scored 7/9 (76%) on the PEDro scale.
There is insufficient evidence to support or refute the effect of exercise on anxiety in PwP due to noted limitations of included studies. There is an urgent need for high-quality RCTs on physical exercise and anxiety in PwP.
焦虑是帕金森病（PD）的一种突出的致残性非运动性神经精神并发症。PD 和焦虑的药物治疗存在药物相互作用和负面副作用。因此，已经提出了非药物干预措施，如运动，以降低 PD 患者（PwP）的焦虑。
本系统评价旨在探讨运动与 PwP 焦虑之间的关系。
在没有时间限制的情况下，对四个数据库（PubMed、Embase、Scopus、Ebscohost）进行了搜索。纳入了包含成年人 PD、接受身体锻炼干预且以焦虑为结局变量的英文随机对照试验（RCT）。采用改良的 9 分 PEDro 量表评估质量。
在确定的 5547 项研究中，有 5 项符合纳入标准。样本量范围为 11-152 名参与者，共有 328 名参与者，其中大多数为男性。PD 阶段从早期到中期不等，疾病持续时间在 2.9 到 8.0 年之间。所有研究均在基线和干预后测量焦虑。平均而言，PEDro 量表的评分为 7/9（76%）。
由于纳入研究的局限性，目前尚无足够的证据支持或反驳运动对 PwP 焦虑的影响。迫切需要针对 PwP 中的身体锻炼和焦虑进行高质量的 RCT。
