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帕金森病伴发抑郁和焦虑的非药物干预措施。

Non-Pharmacological Interventions for Depression and Anxiety in Parkinson's Disease.

机构信息

Department of Rehabilitation Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Amsterdam Movement Sciences, Rehabilitation & Development, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

出版信息

J Parkinsons Dis. 2024;14(s1):S135-S146. doi: 10.3233/JPD-230228.


DOI:10.3233/JPD-230228
PMID:38607762
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11380297/
Abstract

Non-pharmacological interventions, including cognitive-behavioral therapy (CBT), non-invasive brain stimulation (NIBS), electroconvulsive therapy (ECT), light therapy (LT), and physical rehabilitation/exercise, have shown promise as effective approaches to treat symptoms of depression and anxiety in individuals with Parkinson's disease (PD). In this narrative literature overview, we discuss the state-of-the-art regarding these treatment options and address future perspectives for clinical practice and research. Non-pharmacological interventions hold promise to treat depression and anxiety in PD. There is meta-analytic evidence for the efficacy of CBT, NIBS, ECT, LT, and exercise on improving depressive symptoms. For the treatment of anxiety symptoms, CBT shows large effects but scientific evidence of other non-pharmacological interventions is limited. Importantly, these treatments are safe interventions with no or mild side-effects. More research is needed to tailor treatment to the individuals' needs and combined interventions may provide synergistic effects.We conclude that non-pharmacological interventions should be considered as alternative or augmentative treatments to pharmacological and neurosurgical approaches for the treatment of depression and anxiety in individuals with PD.

摘要

非药物干预措施,包括认知行为疗法(CBT)、非侵入性脑刺激(NIBS)、电惊厥疗法(ECT)、光照疗法(LT)和物理康复/运动,已被证明是治疗帕金森病(PD)患者抑郁和焦虑症状的有效方法。在本综述中,我们讨论了这些治疗选择的最新进展,并探讨了未来在临床实践和研究中的前景。非药物干预措施有望治疗 PD 患者的抑郁和焦虑症状。CBT、NIBS、ECT、LT 和运动对改善抑郁症状的疗效有荟萃分析证据。对于焦虑症状的治疗,CBT 显示出较大的效果,但其他非药物干预措施的科学证据有限。重要的是,这些治疗方法是安全的干预措施,几乎没有或仅有轻微的副作用。需要更多的研究来根据个体的需求调整治疗方法,联合干预可能会产生协同作用。我们的结论是,非药物干预措施应被视为 PD 患者抑郁和焦虑治疗的药物和神经外科方法的替代或补充治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cab/11380297/f4f18cf86006/jpd-14-jpd230228-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cab/11380297/f4f18cf86006/jpd-14-jpd230228-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cab/11380297/f4f18cf86006/jpd-14-jpd230228-g001.jpg

相似文献

[1]
Non-Pharmacological Interventions for Depression and Anxiety in Parkinson's Disease.

J Parkinsons Dis. 2024

[2]
Efficacy of cognitive behavioral therapy for anxiety and depression in Parkinson's disease patients: an updated systematic review and meta-analysis.

Neurol Sci. 2024-11

[3]
Cognitive-Behavioral Therapy for Anxiety in Parkinson's Disease.

Behav Modif. 2020-7

[4]
Cognitive Behaviour Therapy for Depression and Anxiety in Parkinson's Disease.

J Parkinsons Dis. 2015

[5]
Pharmacological and Non-Pharmacological Treatments for Depression in Parkinson's Disease: An Updated Review.

Medicina (Kaunas). 2023-8-12

[6]
Study protocol for the MIND-PD study: a randomized controlled trial to investigate clinical and biological effects of mindfulness-based cognitive therapy in people with Parkinson's disease.

BMC Neurol. 2024-6-25

[7]
Psychosocial interventions for depression and anxiety in Parkinson's disease.

J Geriatr Psychiatry Neurol. 2012-6

[8]
Reward and Punishment Learning as Predictors of Cognitive Behavioral Therapy Response in Parkinson's Disease Comorbid with Clinical Depression.

J Geriatr Psychiatry Neurol. 2024-7

[9]
A meta-analysis of randomised placebo-controlled treatment trials for depression and anxiety in Parkinson's disease.

PLoS One. 2013-11-13

[10]
Cognitive behavioral therapy for depression and anxiety of Parkinson's disease: A systematic review and meta-analysis.

Complement Ther Clin Pract. 2020-1-30

引用本文的文献

[1]
Demographic and Clinical Characteristics in Different Motor Subtypes of Parkinson's Disease: How Well Do the Findings Fit Within the Framework of Existing Hypotheses?

Neurol Int. 2025-3-27

[2]
A Usability Pilot Study of a Sensor-Guided Interactive System for Dexterity Training in Parkinson's Disease.

Sensors (Basel). 2025-2-10

本文引用的文献

[1]
(HIIT-The Track) High-Intensity Interval Training for People with Parkinson's Disease: Individual Response Patterns of (Non-)Motor Symptoms and Blood-Based Biomarkers-A Crossover Single-Case Experimental Design.

Brain Sci. 2023-5-24

[2]
Does Exercise Attenuate Disease Progression in People With Parkinson's Disease? A Systematic Review With Meta-Analyses.

Neurorehabil Neural Repair. 2023-5

[3]
Systematic review and meta-analysis of performance of wearable artificial intelligence in detecting and predicting depression.

NPJ Digit Med. 2023-5-5

[4]
The effect of physical exercise on anxiety in people with parkinson's disease: A systematic review of randomized control trials.

NeuroRehabilitation. 2023

[5]
Safety and tolerability of adjunct non-invasive vagus nerve stimulation in people with parkinson's: a study protocol.

BMC Neurol. 2023-2-3

[6]
Effects of non-invasive brain stimulation on walking and balance ability in Parkinson's patients: A systematic review and meta-analysis.

Front Aging Neurosci. 2023-1-10

[7]
Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis.

Cochrane Database Syst Rev. 2023-1-5

[8]
Cognitive Behavioral Therapy for Anxiety in Parkinson's Disease Induces Functional Brain Changes.

J Parkinsons Dis. 2023

[9]
Efficacy of non-pharmacological interventions for depression in individuals with Parkinson's disease: A systematic review and network meta-analysis.

Front Aging Neurosci. 2022-11-10

[10]
Chronobiology of Parkinson's disease: Past, present and future.

Eur J Neurosci. 2023-1

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