Hao Linlin, Zhang Jian, Liu Zhongshan, Lin Xia, Guo Jie
Department of Tumor Radiotherapy, The Second Hospital of Jilin University, Changchun, China.
School of Life Sciences, Department of Biology, Southern University of Science and Technology, Shenzhen, China.
Front Oncol. 2023 Mar 17;13:1145766. doi: 10.3389/fonc.2023.1145766. eCollection 2023.
Biomolecular modifications play an important role in the development of life, and previous studies have investigated the role of DNA and proteins. In the last decade, with the development of sequencing technology, the veil of epitranscriptomics has been gradually lifted. Transcriptomics focuses on RNA modifications that affect gene expression at the transcriptional level. With further research, scientists have found that changes in RNA modification proteins are closely linked to cancer tumorigenesis, progression, metastasis, and drug resistance. Cancer stem cells (CSCs) are considered powerful drivers of tumorigenesis and key factors for therapeutic resistance. In this article, we focus on describing RNA modifications associated with CSCs and summarize the associated research progress. The aim of this review is to identify new directions for cancer diagnosis and targeted therapy.
生物分子修饰在生命发展过程中发挥着重要作用，先前的研究已经探讨了DNA和蛋白质的作用。在过去十年中，随着测序技术的发展，表观转录组学的面纱逐渐被揭开。转录组学关注的是在转录水平上影响基因表达的RNA修饰。随着进一步研究，科学家们发现RNA修饰蛋白的变化与癌症的发生、发展、转移和耐药性密切相关。癌症干细胞（CSCs）被认为是肿瘤发生的强大驱动因素和治疗耐药的关键因素。在本文中，我们重点描述与癌症干细胞相关的RNA修饰，并总结相关研究进展。本综述的目的是确定癌症诊断和靶向治疗的新方向。
