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West Nile Virus Retinopathy and Associations with Long Term Neurological and Neurocognitive Sequelae.西尼罗河病毒视网膜病变及其与长期神经和神经认知后遗症的关联。
PLoS One. 2016 Mar 7;11(3):e0148898. doi: 10.1371/journal.pone.0148898. eCollection 2016.
2
West nile virus occlusive retinal vasculitis.西尼罗河病毒闭塞性视网膜血管炎
Retin Cases Brief Rep. 2011 Summer;5(3):209-12. doi: 10.1097/ICB.0b013e3181e18042.
3
Use of intravitreous bevacizumab to treat macular edema in West Nile virus chorioretinitis.玻璃体内注射贝伐单抗治疗西尼罗河病毒脉络膜视网膜炎所致黄斑水肿。
Arch Ophthalmol. 2012 Mar;130(3):396-8. doi: 10.1001/archopthalmol.2011.1630.
4
Pathogenesis of flavivirus infections: using and abusing the host cell.黄病毒感染的发病机制：利用并滥用宿主细胞
Cell Host Microbe. 2009 Apr 23;5(4):318-28. doi: 10.1016/j.chom.2009.04.001.
5
Occlusive retinal vasculitis in a patient with West Nile virus.西尼罗河病毒感染患者的闭塞性视网膜血管炎
Clin Exp Optom. 2007 Nov;90(6):463-7. doi: 10.1111/j.1444-0938.2007.00140.x.
6
Linear pattern of West Nile virus-associated chorioretinitis is related to retinal nerve fibres organization.西尼罗河病毒相关性脉络膜视网膜炎的线性模式与视网膜神经纤维组织有关。
Eye (Lond). 2007 Jul;21(7):952-5. doi: 10.1038/sj.eye.6702355. Epub 2006 Apr 21.
7
Nucleic acid testing for west nile virus RNA in plasma enhances rapid diagnosis of acute infection in symptomatic patients.检测血浆中西尼罗河病毒RNA的核酸检测可提高有症状患者急性感染的快速诊断率。
J Infect Dis. 2006 May 15;193(10):1361-4. doi: 10.1086/503577. Epub 2006 Apr 4.
8
Ischemic and hemorrhagic retinal vasculitis associated with West Nile virus infection.与西尼罗河病毒感染相关的缺血性和出血性视网膜血管炎。
Retina. 2006 Mar;26(3):365-7. doi: 10.1097/00006982-200603000-00022.
9
Virology, pathology, and clinical manifestations of West Nile virus disease.西尼罗河病毒病的病毒学、病理学及临床表现
Emerg Infect Dis. 2005 Aug;11(8):1174-9. doi: 10.3201/eid1108.050289b.
10
West Nile virus infection in the United States.美国的西尼罗河病毒感染
Arch Neurol. 2004 Aug;61(8):1190-5. doi: 10.1001/archneur.61.8.1190.

脑脊液聚合酶链反应结果为阴性时的西尼罗河病毒脉络膜视网膜炎

West Nile Virus Chorioretinitis in the Presence of Negative Cerebrospinal Fluid Polymerase Chain Reaction Results.

作者信息

Moussa Kareem, Jeng-Miller Karen W, Kim Leo A, Eliott Dean

机构信息

Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA.

出版信息

J Vitreoretin Dis. 2021 Jan 5;5(6):513-519. doi: 10.1177/2474126420979254. eCollection 2021 Nov-Dec.

DOI:10.1177/2474126420979254
PMID:37007175
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9976149/
Abstract

PURPOSE

This work aims to evaluate the utility of nucleic acid amplification testing (NAAT) and serology in confirming West Nile Virus (WNV) infection in patients with suspected WNV chorioretinitis.

METHODS

A retrospective cross-sectional study was conducted of a cluster of patients who presented to the Retina Service of Massachusetts Eye and Ear between September and October 2018.

RESULTS

Three patients were identified with classic WNV chorioretinitis lesions with negative cerebrospinal fluid NAAT and positive serum serology findings. The diagnosis of WNV chorioretinitis was made based on the appearance of the fundus lesions and the presence of characteristic findings on fluorescein angiography as previously described in the literature.

CONCLUSIONS

This report highlights 3 unique cases of WNV chorioretinitis in which NAAT of cerebrospinal fluid failed to identify WNV as the inciting agent. These cases stress the importance of serum serologic testing in diagnosing WNV infection.

摘要

目的

本研究旨在评估核酸扩增检测（NAAT）和血清学检测在确诊疑似西尼罗河病毒（WNV）脉络膜视网膜炎患者的WNV感染中的效用。

方法

对2018年9月至10月间就诊于马萨诸塞州眼耳医院视网膜科的一组患者进行了回顾性横断面研究。

结果

三名患者被确诊为典型的WNV脉络膜视网膜炎病变，脑脊液NAAT检测结果为阴性，血清学检测结果为阳性。WNV脉络膜视网膜炎的诊断基于眼底病变的外观以及荧光素血管造影的特征性表现，如先前文献所述。

结论

本报告突出了3例WNV脉络膜视网膜炎的独特病例，其中脑脊液NAAT未能将WNV鉴定为致病因子。这些病例强调了血清学检测在诊断WNV感染中的重要性。