脑脊液聚合酶链反应结果为阴性时的西尼罗河病毒脉络膜视网膜炎
West Nile Virus Chorioretinitis in the Presence of Negative Cerebrospinal Fluid Polymerase Chain Reaction Results.
作者信息
Moussa Kareem, Jeng-Miller Karen W, Kim Leo A, Eliott Dean
机构信息
Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA.
出版信息
J Vitreoretin Dis. 2021 Jan 5;5(6):513-519. doi: 10.1177/2474126420979254. eCollection 2021 Nov-Dec.
PURPOSE
This work aims to evaluate the utility of nucleic acid amplification testing (NAAT) and serology in confirming West Nile Virus (WNV) infection in patients with suspected WNV chorioretinitis.
METHODS
A retrospective cross-sectional study was conducted of a cluster of patients who presented to the Retina Service of Massachusetts Eye and Ear between September and October 2018.
RESULTS
Three patients were identified with classic WNV chorioretinitis lesions with negative cerebrospinal fluid NAAT and positive serum serology findings. The diagnosis of WNV chorioretinitis was made based on the appearance of the fundus lesions and the presence of characteristic findings on fluorescein angiography as previously described in the literature.
CONCLUSIONS
This report highlights 3 unique cases of WNV chorioretinitis in which NAAT of cerebrospinal fluid failed to identify WNV as the inciting agent. These cases stress the importance of serum serologic testing in diagnosing WNV infection.
目的
本研究旨在评估核酸扩增检测（NAAT）和血清学检测在确诊疑似西尼罗河病毒（WNV）脉络膜视网膜炎患者的WNV感染中的效用。
方法
对2018年9月至10月间就诊于马萨诸塞州眼耳医院视网膜科的一组患者进行了回顾性横断面研究。
结果
三名患者被确诊为典型的WNV脉络膜视网膜炎病变，脑脊液NAAT检测结果为阴性，血清学检测结果为阳性。WNV脉络膜视网膜炎的诊断基于眼底病变的外观以及荧光素血管造影的特征性表现，如先前文献所述。
结论
本报告突出了3例WNV脉络膜视网膜炎的独特病例，其中脑脊液NAAT未能将WNV鉴定为致病因子。这些病例强调了血清学检测在诊断WNV感染中的重要性。
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