Khairallah M, Ben Yahia S, Attia S, Zaouali S, Ladjimi A, Messaoud R
Department of Ophthalmology, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Eye (Lond). 2007 Jul;21(7):952-5. doi: 10.1038/sj.eye.6702355. Epub 2006 Apr 21.
To clarify the reason for the linear pattern of West Nile virus (WNV)-associated chorioretinitis.
The study included 12 patients (24 eyes) with WNV-associated chorioretinitis. All the patients underwent a complete ophthalmic evaluation, including dilated fundus examination, fundus photography, fluorescein angiography, and indocyanine green angiography. Characteristics of linear streaks, particularly their relationship to the course of retinal and choroidal vessels, and pattern of retinal nerve fibres, were analysed.
All patients had bilateral multifocal chorioretinitis with linear clustering of chorioretinal lesions associated with a variable number of scattered lesions. Linear streaks, variable in number and length, originated from the optic disc or its vicinity in most cases. Their course in all cases appeared to closely follow the course of retinal nerve fibres, rather than that of retinal or choroidal vessels.
Results of our study show that the linear pattern of WNV-associated chorioretinitis is related to retinal nerve fibres organization, suggesting a contiguous spread of WNV virus from central nerve system via the optic nerve fibres to the outer retina, retinal pigment epithelium, and choroid.
阐明西尼罗河病毒（WNV）相关性脉络膜视网膜炎呈现线性模式的原因。
该研究纳入了12例（24只眼）WNV相关性脉络膜视网膜炎患者。所有患者均接受了全面的眼科评估，包括散瞳眼底检查、眼底照相、荧光素血管造影和吲哚菁绿血管造影。分析了线性条纹的特征，特别是它们与视网膜和脉络膜血管走行的关系以及视网膜神经纤维的形态。
所有患者均患有双侧多发性脉络膜视网膜炎，脉络膜视网膜病变呈线性聚集，并伴有数量不等的散在病变。线性条纹数量和长度各异，多数情况下起源于视盘或其附近。在所有病例中，它们的走行似乎紧密跟随视网膜神经纤维的走行，而非视网膜或脉络膜血管的走行。
我们的研究结果表明，WNV相关性脉络膜视网膜炎的线性模式与视网膜神经纤维的组织结构有关，提示WNV病毒从中枢神经系统经视神经纤维向视网膜外层、视网膜色素上皮和脉络膜呈连续性扩散。
