Schoenwolf G C, Desmond M E
J Comp Neurol. 1986 Apr 22;246(4):459-66. doi: 10.1002/cne.902460404.
Occlusion and reopening of the spinal neurocele are important morphogenetic events occurring during rapid brain enlargement in amphibians, birds, and mammals. The purpose of the present study, a companion to a previous one on occlusion, is to examine reopening. We determined when reopening occurred and at what frequency, whether it occurred suddenly or gradually, the extents of the neurocele that were patent at particular stages of reopening, and the morphological pattern of reopening. Reopening begins at stages 14+ to 15 and is virtually complete at stages 16-17. Thus, reopening of the spinal neurocele occurs suddenly and occlusion is a relatively short-lived developmental event. Because rapid brain enlargement still occurs after reopening, occlusion probably functions principally in the initial phases of enlargement prior to closure of the posterior neuropore. Further studies on the mechanisms of occlusion and reopening are under way.
脊髓神经管的闭合和重新开放是两栖动物、鸟类和哺乳动物大脑快速发育过程中发生的重要形态发生事件。本研究作为之前关于神经管闭合研究的姊妹篇，旨在研究神经管的重新开放。我们确定了重新开放发生的时间和频率，它是突然发生还是逐渐发生，在重新开放的特定阶段开放的神经管范围，以及重新开放的形态模式。重新开放始于14 +至15期，在16 - 17期基本完成。因此，脊髓神经管的重新开放是突然发生的，而闭合是一个相对短暂的发育事件。由于重新开放后大脑仍在快速发育，神经管闭合可能主要在后部神经孔闭合前的发育初期起作用。关于神经管闭合和重新开放机制的进一步研究正在进行中。
