Schoenwolf G C, Desmond M E
J Exp Zool. 1984 Jun;230(3):405-7. doi: 10.1002/jez.1402300309.
Histological examination of early vertebrate embryos during rapid brain enlargement (an event partially driven by fluid pressure) reveals that the spinal cord lumen is occluded. Occlusion (if it is not merely a fixation artifact) may confine neural tube fluid to brain regions and seal off the ventricles before posterior neuropore closure. We injected neural tubes of living chick embryos with dyes, asking (1) is occlusion real; and (2) does occlusion precede brain enlargement? Both questions were answered affirmatively. Experimental analyses of occlusion and brain enlargement are in progress.
对快速脑扩张（这一过程部分由流体压力驱动）期间的早期脊椎动物胚胎进行组织学检查发现，脊髓管腔被阻塞。阻塞（如果不仅仅是固定假象）可能会将神经管液限制在脑区，并在神经孔后闭合之前封闭脑室。我们向活鸡胚胎的神经管中注射染料，以探究（1）阻塞是真实存在的吗；（2）阻塞是否先于脑扩张？这两个问题的答案都是肯定的。目前正在对阻塞和脑扩张进行实验分析。
