Gavanji Shahin, Bakhtari Azizollah, Baghshahi Hojjat, Chamgordani Zahra Hamami, Sadeghi Akram
Department of Biotechnology, Faculty of Advanced Sciences and Technologies, University of Isfahan, Isfahan, Iran.
Department of Reproductive Biology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
J Pharmacopuncture. 2023 Mar 31;26(1):53-59. doi: 10.3831/KPI.2023.26.1.53.
The most prominent microorganisms that cause hospital infections and acquire antibiotic resistance are and . The present study aimed to compare the phenolic and flavonoid compounds of various and extracts and evaluate the antibacterial effects of these extracts against these two microorganisms.
The total phenolic and flavonoid contents of the acetone, methanol, aqueous, and hexane leeks extracts from and were measured. The antibacterial activity of these extracts against and was tested using the disk diffusion method for 24, 48, and 72 hours. Further, the minimum inhibitory concentrations and the minimum bactericidal concentrations of these extracts for these two bacteria were evaluated and compared with those of common antibiotics.
The aqueous extracts showed the highest phenolic and flavonoid contents and at concentrations of 35 and 40 mg per disk, showed the most antibacterial activity against and ; showed more sensitivity to the aqueous extracts than .
Aqueous and extracts may prevent the growth of hospital pathogens, especially ; our findings will aid the discovery of new antimicrobial substances against antibiotic-resistant bacteria.
引起医院感染并获得抗生素耐药性的最主要微生物是[具体微生物1]和[具体微生物2]。本研究旨在比较不同[植物名称1]和[植物名称2]提取物中的酚类和黄酮类化合物，并评估这些提取物对这两种微生物的抗菌作用。
测定了[植物名称1]和[植物名称2]的丙酮、甲醇、水和己烷韭菜提取物中的总酚和总黄酮含量。使用纸片扩散法对这些提取物对[具体微生物1]和[具体微生物2]的抗菌活性进行了24、48和72小时的测试。此外，评估了这些提取物对这两种细菌的最低抑菌浓度和最低杀菌浓度，并与常用抗生素进行了比较。
水提取物显示出最高的酚类和黄酮类含量，在每片35和40毫克的浓度下，对[具体微生物1]和[具体微生物2]表现出最强的抗菌活性；[具体微生物1]对水提取物的敏感性高于[具体微生物2]。
[植物名称1]和[植物名称2]的水提取物可能会抑制医院病原体的生长，尤其是[具体微生物1]；我们的研究结果将有助于发现针对耐药细菌的新型抗菌物质。
