Abu-Abaa Mohammad, Al-Qaysi Ghassan, Chadalawada Sindhu, Cole Adedeji
Internal Medicine, Capital Health Regional Medical Center, Trenton, USA.
Cureus. 2023 Feb 28;15(2):e35584. doi: 10.7759/cureus.35584. eCollection 2023 Feb.
Catastrophic antiphospholipid antibody syndrome (CAPS) is a life-threatening disorder. It is a rare and severe form of antiphospholipid antibody (APL) syndrome characterized by widespread multisystemic thrombosis. We present a 55-year-old male patient with acute cerebellar hemorrhagic stroke who developed widespread progressive microthrombosis and macrothrombosis manifesting as progressive bilateral ischemic strokes with lower extremities deep vein thrombosis (DVT) and acute renal failure within a week of presentation. The diagnosis and initiation of therapy were established after serological confirmation. This case adds to a limited number of cases of CAPS in literature and is interesting given the rarity of CAPS and thrombotic storm (TS) as well as the lack of inciting factor triggering CAPS/thrombotic syndrome. This case also helps to remind the clinicians of the importance to consider CAPS, even prior to serological confirmation, in those with rapidly progressive thrombotic events, as delayed diagnosis and therapy can yield poor clinical outcomes.
灾难性抗磷脂抗体综合征（CAPS）是一种危及生命的疾病。它是抗磷脂抗体（APL）综合征的一种罕见且严重的形式，其特征为广泛的多系统血栓形成。我们报告一例55岁男性急性小脑出血性卒中患者，该患者在发病一周内出现广泛进展性微血栓形成和大血栓形成，表现为进行性双侧缺血性卒中、下肢深静脉血栓形成（DVT）和急性肾衰竭。血清学确诊后确立诊断并开始治疗。该病例补充了文献中有限的CAPS病例数量，鉴于CAPS和血栓风暴（TS）的罕见性以及缺乏引发CAPS/血栓综合征的诱发因素，该病例很有意思。该病例还有助于提醒临床医生，对于那些有快速进展性血栓事件的患者，即使在血清学确诊之前也应考虑CAPS的重要性，因为延迟诊断和治疗可能导致不良临床结局。
