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一名未接种疫苗的患者在感染新冠病毒后出现类似血小板减少伴血栓形成综合征的血栓形成与无巨核细胞性血小板减少合并症的罕见病例。

An Unusual Case of Combined Thrombosis and Amegakaryocytopenia Resembling Thrombosis With Thrombocytopenia Syndrome Following COVID-19 Infection in an Unvaccinated Patient.

作者信息

Hassan Mariam, Prakash Swathi, Rayas Jose, Bies Jared J, Reddy Sukhila, Nadella Sahithi, Alhariri Sara, Radwan Yousf, Hakim Nawar, Corral Javier

机构信息

Internal Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, USA.

Pathology, Texas Tech University Health Sciences Center El Paso, El Paso, USA.

出版信息

Cureus. 2023 Feb 27;15(2):e35530. doi: 10.7759/cureus.35530. eCollection 2023 Feb.

DOI:10.7759/cureus.35530
PMID:37007352
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10054843/
Abstract

As a global community, we have learned that the manifestations of severe acute respiratory syndrome coronavirus 2 (SAR-CoV-2), infection, or coronavirus disease 2019 (COVID-19), extends far beyond respiratory compromise. Thrombocytopenia is thought to occur secondary to increased platelet consumption. Platelet activation and platelet-mediated immune inflammation contribute towards the thromboembolic complications seen in COVID-19 patients. In this report, the authors present the unusual case of a 75-year-old female with a history of COVID-19 infection who presented with a transient ischemic attack, thrombocytopenia, and amegakaryocytopenia.

摘要

作为一个全球共同体，我们已经了解到严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染或2019冠状病毒病（COVID-19）的表现远远超出了呼吸功能损害。血小板减少被认为是继发于血小板消耗增加。血小板活化和血小板介导的免疫炎症促成了COVID-19患者出现的血栓栓塞并发症。在本报告中，作者介绍了一例不同寻常的病例，一名75岁有COVID-19感染史的女性出现了短暂性脑缺血发作、血小板减少和无巨核细胞血症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d51c/10054843/922d1645e0df/cureus-0015-00000035530-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d51c/10054843/8e27346bf992/cureus-0015-00000035530-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d51c/10054843/922d1645e0df/cureus-0015-00000035530-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d51c/10054843/8e27346bf992/cureus-0015-00000035530-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d51c/10054843/922d1645e0df/cureus-0015-00000035530-i02.jpg

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本文引用的文献

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Understanding thrombosis with thrombocytopenia syndrome after COVID-19 vaccination.了解新冠病毒疫苗接种后伴有血小板减少的血栓形成综合征
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Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination.ChAdOx1新冠疫苗接种后的血栓形成和血小板减少症
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