中国海南省一起由携带ST7基因引起的食物中毒事件。
A food poisoning caused by ST7 harboring gene in Hainan province, China.
作者信息
Guo Yahui, Yu Xiaojie, Wang Jixiao, Hua De, You Yuanhai, Wu Qingbo, Ji Qinglong, Zhang Jianzhong, Li Liefei, Hu Yuan, Wu Zhonghui, Wei Xiaoyue, Jin Lianqun, Meng Fanliang, Yang Yuhua, Hu Xiaofeng, Long Lijin, Hu Songnian, Qi Heyuan, Ma Juncai, Bei Wenwen, Yan Xiaomei, Wang Haibin, He Zilong
机构信息
Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, China.
Chinese Center for Disease Control and Prevention, National Institute for Communicable Disease Control and Prevention, Beijing, China.
出版信息
Front Microbiol. 2023 Mar 16;14:1110720. doi: 10.3389/fmicb.2023.1110720. eCollection 2023.
ST7 is highly prevalent in humans, pigs, as well as food in China; however, staphylococcal food poisoning (SFP) caused by this ST type has rarely been reported. On May 13, 2017, an SFP outbreak caused by ST7 strains occurred in two campuses of a kindergarten in Hainan Province, China. We investigated the genomic characteristics and phylogenetic analysis of ST7 SFP strains combined with the 91 ST7 food-borne strains from 12 provinces in China by performing whole-genome sequencing (WGS). There was clear phylogenetic clustering of seven SFP isolates. Six antibiotic genes including and were present in all SFP strains and also showed a higher prevalence rate in 91 food-borne strains. A multiple resistance plasmid pDC53285 was present in SFP strain DC53285. Among 27 enterotoxin genes, only and were found in all SFP strains. A ФSa3int prophage containing type A immune evasion cluster (, and ) was identified in SFP strain. In conclusion, we concluded that this SFP event was caused by the contamination of cakes with ST7 . This study indicated the potential risk of new emergencing ST7 clone for SFP.
ST7在中国的人类、猪以及食品中高度流行；然而，由这种ST型引起的葡萄球菌食物中毒（SFP）鲜有报道。2017年5月13日，中国海南省一所幼儿园的两个校区发生了由ST7菌株引起的SFP疫情。我们通过全基因组测序（WGS）对ST7 SFP菌株以及来自中国12个省份的91株ST7食源性菌株进行了基因组特征分析和系统发育分析。7株SFP分离株存在明显的系统发育聚类。所有SFP菌株中均存在包括和在内的6种抗生素基因，在91株食源性菌株中也显示出较高的流行率。SFP菌株DC53285中存在一个多重耐药质粒pDC53285。在27种肠毒素基因中，仅在所有SFP菌株中发现了和。在SFP菌株中鉴定出一个含有A型免疫逃避簇（、和）的ФSa3int前噬菌体。总之，我们得出结论，此次SFP事件是由蛋糕被ST7污染所致。本研究表明新出现的ST7克隆对SFP存在潜在风险。
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