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引用本文的文献

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本文引用的文献

1
Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis.HIV 相关隐球菌性脑膜炎的全球疾病负担：最新分析
Lancet Infect Dis. 2017 Aug;17(8):873-881. doi: 10.1016/S1473-3099(17)30243-8. Epub 2017 May 5.
2
Eye examination for early diagnosis of disseminated tuberculosis in patients with AIDS.眼部检查在 AIDS 患者中早期诊断播散性肺结核。
Lancet Infect Dis. 2016 Apr;16(4):493-9. doi: 10.1016/S1473-3099(15)00269-8. Epub 2016 Feb 18.
3
Primary bilateral multifocal choroiditis as an initial manifestation of disseminated cryptococcosis in a HIV-positive patient.原发性双侧多灶性脉络膜炎作为一名HIV阳性患者播散性隐球菌病的初始表现。
Ocul Immunol Inflamm. 2008 Jul-Aug;16(4):191-3. doi: 10.1080/09273940802204568.
4
Discontinuation of highly active antiretroviral therapy leads to cryptococcal meningitis/choroiditis in an AIDS patient.在一名艾滋病患者中，停用高效抗逆转录病毒疗法导致隐球菌性脑膜炎/脉络膜炎。
Optometry. 2006 Sep;77(9):438-45. doi: 10.1016/j.optm.2006.06.005.
5
Presumed multifocal cryptococcol choroidopathy prior to specific systemic manifestation.在出现特定全身表现之前的疑似多灶性隐球菌脉络膜病变。
Int Ophthalmol. 1997;21(2):75-8. doi: 10.1023/a:1005810624388.
6
Ocular manifestations of HIV infection.HIV感染的眼部表现。
Trans Am Ophthalmol Soc. 1995;93:623-83.
7
Infectious multifocal choroiditis in patients with acquired immune deficiency syndrome.获得性免疫缺陷综合征患者的感染性多灶性脉络膜炎。
Ophthalmology. 1993 Jul;100(7):1014-21. doi: 10.1016/s0161-6420(93)31543-5.
8
Ophthalmic manifestations of infections with Cryptococcus neoformans in patients with the acquired immunodeficiency syndrome.获得性免疫缺陷综合征患者新型隐球菌感染的眼部表现。
Am J Ophthalmol. 1993 Dec 15;116(6):721-7. doi: 10.1016/s0002-9394(14)73472-5.
9
A clinical, histopathologic, and electron microscopic study of Pneumocystis carinii choroiditis.卡氏肺孢子虫脉络膜炎的临床、组织病理学及电子显微镜研究
Am J Ophthalmol. 1989 Mar 15;107(3):218-28. doi: 10.1016/0002-9394(89)90303-6.
10
The spectrum of optic nerve disease in human immunodeficiency virus infection.人类免疫缺陷病毒感染中的视神经疾病谱
Am J Ophthalmol. 1989 Apr 15;107(4):373-80. doi: 10.1016/0002-9394(89)90660-0.

一名患有脑膜炎和播散性隐球菌病的HIV阳性患者的双侧板层脉络膜炎

Bilateral Placoid Choroiditis in an HIV-Positive Patient With Meningitis and Disseminated Cryptococcal Disease.

作者信息

Larochelle Ryan D, Larochelle Marissa B, Aung Yee Yee, Linn Thinzar, Heiden David, Vitale Albert T

机构信息

Department of Ophthalmology, University of Colorado, Denver, CO, USA.

Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, UT, USA.

出版信息

J Vitreoretin Dis. 2020 Jul 21;4(6):530-533. doi: 10.1177/2474126420936191. eCollection 2020 Nov-Dec.

DOI:10.1177/2474126420936191
PMID:37007659
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9976065/
Abstract

PURPOSE

We report a presumptive case of bilateral placoid choroiditis secondary to disseminated infection and review the literature on choroidal involvement of .

METHODS

A case report is presented.

RESULTS

A 35-year-old HIV-positive man presented with disseminated cryptococcal infection. Cryptococcal meningitis was confirmed by lumbar puncture, and skin involvement was confirmed by microscopy of scrapings from a papular, umbilicated, ulcerated lesion. Ophthalmologic examination revealed intact visual acuity, clear vitreous, and multiple yellowish, placoid-appearing choroidal lesions in the posterior pole bilaterally.

CONCLUSIONS

Multifocal choroiditis caused by is an uncommon manifestation of disseminated infection, and placoid yellowish choroidal lesions are an unusual variant. These findings must be differentiated from choroidal tuberculosis and other infections. Multifocal choroiditis typically occurs in AIDS patients and may precede the presentation of meningitis. In such patients, choroidal lesions warrant investigation for systemic, life-threatening opportunistic infections.

摘要

目的

我们报告一例继发于播散性感染的双侧扁平状脉络膜炎的疑似病例，并复习有关脉络膜受累的文献。

方法

呈现一例病例报告。

结果

一名35岁的HIV阳性男性出现播散性隐球菌感染。腰椎穿刺确诊为隐球菌性脑膜炎，通过对丘疹、脐状、溃疡性病变刮片的显微镜检查确诊皮肤受累。眼科检查显示视力正常、玻璃体清晰，双侧后极部有多个淡黄色、扁平状脉络膜病变。

结论

由[未提及具体病原体]引起的多灶性脉络膜炎是播散性感染的一种罕见表现，而扁平状淡黄色脉络膜病变是一种不寻常的变异。这些发现必须与脉络膜结核和其他感染相鉴别。多灶性脉络膜炎通常发生在艾滋病患者中，可能在脑膜炎出现之前发生。在此类患者中，脉络膜病变需要调查是否存在全身性、危及生命的机会性感染。