Winkelmann R K, Frigas E
J Cutan Pathol. 1986 Feb;13(1):1-12. doi: 10.1111/j.1600-0560.1986.tb00455.x.
Study of 18 patients with biopsy diagnoses of eosinophilic panniculitis revealed diverse patterns of systemic disease, including Wells' syndrome, vasculitis, atopy, and erythema nodosum as well as localized panniculitis. Significant associated diseases included psychiatric illness, 6 (drug dependency, 4); atopy, 5 (asthma, 3); malignancies, 5; immune complex vasculitis, 4; thyroid disease, 2; Wells' eosinophilic cellulitis, 2; glomerulonephritis and sarcoidosis, 1 each. The skin lesions varied from urticarial papules and plaques to purpura, pustules, and ulcerative lesions but always included a nodular subcutaneous component, frequently as a presenting complaint. Eosinophilic panniculitis is a non-specific finding that can signify localized disease, such as an insect bite or injection lipophagic granuloma in a drug-dependent patient, or systemic lymphoma or immune reactive disease. Eosinophilic panniculitis in erythema nodosum is perhaps its most confusing presentation.
对18例经活检诊断为嗜酸性脂膜炎的患者进行研究，发现其系统性疾病模式多样，包括韦尔斯综合征、血管炎、特应性疾病、结节性红斑以及局限性脂膜炎。显著的相关疾病包括精神疾病6例（药物依赖4例）；特应性疾病5例（哮喘3例）；恶性肿瘤5例；免疫复合物性血管炎4例；甲状腺疾病2例；韦尔斯嗜酸性蜂窝织炎2例；肾小球肾炎和结节病各1例。皮肤损害从荨麻疹样丘疹和斑块到紫癜、脓疱及溃疡性损害不等，但始终包括皮下结节成分，且常以此作为首发症状。嗜酸性脂膜炎是一种非特异性表现，可提示局限性疾病，如药物依赖患者的昆虫叮咬或注射性脂肪吞噬性肉芽肿，或系统性淋巴瘤或免疫反应性疾病。结节性红斑中的嗜酸性脂膜炎可能是其最令人困惑的表现。
