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低钠血症作为无症状HIV感染者和隐球菌抗原血症患者隐球菌性脑膜炎及死亡的预测指标

Hyponatremia as a Predictor of Cryptococcal Meningitis and Death Among Asymptomatic Persons With HIV and Cryptococcal Antigenemia.

作者信息

Lehman Alice, Nalintya Elizabeth, Wele Abduljewad, Kirumira Paul, Naluyima Rose, Namuli Teopista, Turya Musa Fred, Skipper Caleb P, Meya David B, Boulware David R, Rajasingham Radha

机构信息

Division of Infectious Diseases and International Medicine, University of Minnesota, Minneapolis, Minnesota, USA.

Infectious Disease Institute, Makerere University, Kampala, Uganda.

出版信息

Open Forum Infect Dis. 2023 Mar 28;10(3):ofad156. doi: 10.1093/ofid/ofad156. eCollection 2023 Mar.

DOI:10.1093/ofid/ofad156
PMID:37008569
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10061560/
Abstract

Among persons with human immunodeficiency virus-associated cryptococcal meningitis serum hyponatremia is a risk factor for mortality; however, the role of hyponatremia in persons with asymptomatic cryptococcal antigenemia is unknown. We found that serum hyponatremia ≤130 mmol/L is an independent risk factor for progression to meningitis and death in asymptomatic persons with cryptococcal antigenemia.

摘要

在人类免疫缺陷病毒相关隐球菌性脑膜炎患者中，血清低钠血症是死亡的危险因素；然而，低钠血症在无症状隐球菌抗原血症患者中的作用尚不清楚。我们发现，血清低钠血症≤130 mmol/L是无症状隐球菌抗原血症患者进展为脑膜炎和死亡的独立危险因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d368/10061560/89a6e69db091/ofad156f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d368/10061560/89a6e69db091/ofad156f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d368/10061560/89a6e69db091/ofad156f1.jpg

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Hyponatremia in tuberculous meningitis: A systematic review and meta-analysis.
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Electrolyte Disorders and the Nervous System.电解质紊乱与神经系统
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