Wen Hainan, Xie Shoujun, Liu Yanchao, Liang Yueyi, Zhang Pan, Wang Xiaohui, Li Jianhui
Department of Clinical Laboratory, Affiliated Hospital of Chengde Medical University, Chengde, Hebei, People's Republic of China.
Department of Preventive Medicine, Chengde Medical University, Chengde, Hebei, People's Republic of China.
Infect Drug Resist. 2023 Mar 27;16:1753-1765. doi: 10.2147/IDR.S401341. eCollection 2023.
have displayed widespread trends of antimicrobial resistance in recent years. Therefore, we aimed to analyse the antimicrobial susceptibility of common bacteria and explore the significance in treatment and research of infections induced by .
We retrospectively analysed 10,775 antimicrobial susceptibility test results acquired over a 6-year period in the affiliated hospital of Chengde Medical University. We divided the data based on specimen type (blood, sputum, pus, or urine), and population characteristics (age bracket and sex) for analysis. We mainly analysed the antimicrobial susceptibility of (Eco), (Kpn), and (Ecl).
In our study, it was found that the resistance rates of Eco, Kpn, and Ecl to most antimicrobial agents were significantly different ( < 0.05) on specimen type and age bracket. The Eco from sputum had the highest resistance rates except ciprofloxacin (CIP), levofloxacin (LVX), and gentamicin (GEN); the Kpn from urine had the highest resistance rates to all antimicrobial agents; the Ecl from urine had the highest resistance rates to most antimicrobial agents. The Eco from geriatric patients had the highest resistance rates except GEN and SXT; the Kpn from adult patients had the lowest resistance rates to most antimicrobial agents except LVX. The Eco isolated from males had higher resistance rates to most antimicrobial agents except CIP, LVX, and NIT than those isolated from females; the Kpn showed significant differences in antimicrobial susceptibility to only 5 out of 22 antimicrobial agents ( < 0.05); the Ecl showed significant differences in susceptibility only to two antimicrobial agents, LVX and TOB ( < 0.01).
The antimicrobial susceptibility of was significantly different among specimen type, age bracket and sex of patients, which is of great significance for the treatment and research of infection.
近年来已呈现出广泛的抗菌药物耐药趋势。因此，我们旨在分析常见细菌的抗菌药物敏感性，并探讨其在[具体细菌名称]所致感染的治疗和研究中的意义。
我们回顾性分析了承德医学院附属医院6年间获得的10775份抗菌药物敏感性试验结果。我们根据标本类型（血液、痰液、脓液或尿液）和人群特征（年龄组和性别）对数据进行分类分析。我们主要分析了[具体细菌名称1]（大肠杆菌，Eco）、[具体细菌名称2]（肺炎克雷伯菌，Kpn）和[具体细菌名称3]（阴沟肠杆菌，Ecl）的抗菌药物敏感性。
在我们的研究中，发现大肠杆菌、肺炎克雷伯菌和阴沟肠杆菌对大多数抗菌药物的耐药率在标本类型和年龄组方面存在显著差异（P<0.05）。痰液中的大肠杆菌除对环丙沙星（CIP）、左氧氟沙星（LVX）和庆大霉素（GEN）外，耐药率最高；尿液中的肺炎克雷伯菌对所有抗菌药物的耐药率最高；尿液中的阴沟肠杆菌对大多数抗菌药物的耐药率最高。老年患者的大肠杆菌除对GEN和复方新诺明（SXT）外，耐药率最高；成年患者的肺炎克雷伯菌对大多数抗菌药物（除LVX外）的耐药率最低。从男性分离出的大肠杆菌除对CIP、LVX和呋喃妥因（NIT）外，对大多数抗菌药物的耐药率高于从女性分离出的大肠杆菌；肺炎克雷伯菌仅在22种抗菌药物中的5种上显示出抗菌药物敏感性的显著差异（P<0.05）；阴沟肠杆菌仅对两种抗菌药物LVX和妥布霉素（TOB）的敏感性存在显著差异（P<0.01）。
[具体细菌名称]的抗菌药物敏感性在患者的标本类型、年龄组和性别之间存在显著差异，这对感染的治疗和研究具有重要意义。
