Powers James H, Wisely C Ellis, Sastry Ananth, Fekrat Sharon
Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA.
J Vitreoretin Dis. 2019 Dec 31;4(4):327-331. doi: 10.1177/2474126419895692. eCollection 2020 Jul-Aug.
This report discusses a case of neovascular age-related macular degeneration with mixed serous pigment epithelial detachment (PED) that was unresponsive to antivascular endothelial growth injections but responded to the addition of intravitreal steroid injection.
We report a case.
A 75-year-old woman with neovascular age-related macular degeneration developed a mixed serous PED in her right eye. Three monthly aflibercept (Eylea, Regeneron) treatments led to resolution of associated intraretinal fluid; however, the mixed serous and fibrovascular PED significantly increased in size. The addition of intravitreal dexamethasone (Ozurdex, Allergan) to monthly aflibercept led to prompt flattening of the PED. Three months later, the PED recurred despite continued administration of monthly aflibercept.
This case supports a growing body of research that PEDs unresponsive to antivascular endothelial growth injections may respond to intravitreal steroid injections.
本报告讨论了一例伴有混合性浆液性色素上皮脱离（PED）的新生血管性年龄相关性黄斑变性病例，该病例对抗血管内皮生长因子注射无反应，但玻璃体腔注射类固醇后有反应。
我们报告了一例病例。
一名75岁患有新生血管性年龄相关性黄斑变性的女性右眼出现混合性浆液性PED。每月三次阿柏西普（Eylea，再生元公司）治疗使相关视网膜内液消退；然而，混合性浆液性和纤维血管性PED的大小显著增加。在每月一次阿柏西普治疗基础上加用玻璃体腔地塞米松（Ozurdex，艾尔建公司）后，PED迅速变平。三个月后，尽管继续每月注射阿柏西普，PED仍复发。
该病例支持了越来越多的研究，即对抗血管内皮生长因子注射无反应的PED可能对玻璃体腔注射类固醇有反应。
