V Pasyechnikova Nataliya, A Naumenko Volodymyr, R Korol Andrii, S Zadorozhnyy Oleg, B Kustrin Taras, O Nasinnyk Illya
The Filatov Institute of Eye Diseases and Tissue Therapy of NAMS of Ukraine, Odessa, Ukraine.
Med Hypothesis Discov Innov Ophthalmol. 2012 Winter;1(4):72-5.
To evaluate the effects of intravitreal triamcinolone acetonide (TA) as a monotherapy of serous Pigment Epithelial Detachment (PED) associated with AMD (Age-Related Macular Degeneration), this study has been performed. Seventeen patients (19 eyes) with serous PED associated with AMD were observed. All patients received 0.1ml (4mg) of intravitreal TA. The mean follow-up period was 18 months. Re-attachment of serous PED was observed in 37% of cases to the end of follow-up. In other cases, the height and length of serous PED significantly decreased. Visual acuity remained stable in all cases. No evidence of RPE tear or CNV development were noted. Before TA administration, intraocular pressure (IOP) was 20.18 ± 2.58 mmHg however, after intravitreal TA, IOP increased gradually and reached its maximum of all period of observation (23.25±1.85mmHg) six months after injection (P=0.031). In 7 (37%) of the cases, progression to cataract was observed after treatment. After surgery, the visual acuity in all cases increased by 0.2 to 0.5. As a conclusion, intravitreal TA decreases of both the height and length of serous PED associated with AMD after 18 months follow-up in most cases. The presented data provides support for the hypothesis regarding the possibility of monotherapy of serous PED with intravitreal TA.
为评估玻璃体内注射曲安奈德（TA）作为湿性年龄相关性黄斑变性（AMD）相关的浆液性色素上皮脱离（PED）单一疗法的效果，进行了本研究。观察了17例（19只眼）与AMD相关的浆液性PED患者。所有患者均接受了0.1ml（4mg）玻璃体内TA注射。平均随访期为18个月。随访结束时，37%的病例观察到浆液性PED重新附着。在其他病例中，浆液性PED的高度和长度显著降低。所有病例的视力均保持稳定。未观察到视网膜色素上皮（RPE）撕裂或脉络膜新生血管（CNV）形成的证据。在注射TA前，眼内压（IOP）为20.18±2.58mmHg，然而，玻璃体内注射TA后，IOP逐渐升高，并在注射后6个月达到观察期内的最高值（23.25±1.85mmHg）（P=0.031）。7例（37%）病例在治疗后出现白内障进展。手术后，所有病例的视力提高了0.2至0.5。结论是，在大多数病例中，经过18个月的随访，玻璃体内TA可降低与AMD相关的浆液性PED的高度和长度。所提供的数据支持了关于玻璃体内TA单一治疗浆液性PED可能性的假设。
