绘制[具体生物名称]和[具体生物名称]中的结构变异图谱揭示了媒介-病原体适应性。（你提供的原文中“in and ”部分缺失具体信息）

Mapping structural variations in and reveals vector-pathogen adaptation.

作者信息

Liu Qi, Yang Ke, Xie Bo, Gao Yang, Xu Shuhua, Lu Yan

机构信息

State Key Laboratory of Genetic Engineering, Center for Evolutionary Biology, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University, Shanghai 201203, China.

Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

出版信息

iScience. 2023 Mar 14;26(4):106398. doi: 10.1016/j.isci.2023.106398. eCollection 2023 Apr 21.

DOI:10.1016/j.isci.2023.106398

PMID:37009216

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10060689/

Abstract

As the most common vector only second to mosquitoes, ticks pose an increasing threat to public health and cause economic losses. However, the genomic variations of ticks remain largely unknown. Here, we conducted the first whole-genome sequencing-based analysis of structural variation (SV) to understand the biology and evolution of ticks. We identified 8,370 and 11,537 SVs in 156 and 138 , respectively. Different from the close relationship of . , . can be clustered into three distinct geographic populations. We also identified a 5.2-kb deletion in gene in . and a 4.1-kb duplication in the gene in . ; both are likely associated with vector-pathogen adaptation. Our study provided a whole-genome SV map and identified SVs associated with the development and evolution of tick species, which could be candidates for the prevention and control of ticks.

摘要

作为仅次于蚊子的最常见病媒，蜱虫对公众健康构成越来越大的威胁，并造成经济损失。然而，蜱虫的基因组变异在很大程度上仍不为人知。在此，我们进行了首次基于全基因组测序的结构变异（SV）分析，以了解蜱虫的生物学特性和进化情况。我们分别在156只和138只蜱虫中鉴定出8370个和11537个结构变异。与……的密切关系不同，……可分为三个不同的地理种群。我们还在……的……基因中鉴定出一个5.2千碱基的缺失，在……的……基因中鉴定出一个4.1千碱基的重复；两者都可能与病媒-病原体适应性有关。我们的研究提供了一张全基因组结构变异图谱，并鉴定出与蜱虫物种发育和进化相关的结构变异，这些变异可能是蜱虫预防和控制的候选对象。